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How Long Does Tadalafil Last? Exploring the Duration of Tadalafil’s Effects

Julian Carter


how long does tadalafil last

Erectile Dysfunction, or ED, can be treated with the help of Tadalafil, sold under the brand name Cialis. Tadalafil is a PDE5 inhibitor.

How long does Tadalafil last? This is one of the most frequently asked questions regarding this medication.

In this article, we will discuss the various factors that determine how long the Tadalafil’s effects last and offer some advice on how to get the most out of them.

Tadalafil duration: How long it lasts

The duration of Tadalafil’s effects can vary from person to person. Typically, Tadalafil (know by its brand-name Cialis) remains active in the body for up to 36 hours

This extended duration of action for treating Erectile Dysfunction has earned it the nickname “the weekend pill” among users. 

It gives you a longer window of opportunity for sexual activity compared to other Erectile Dysfunction pills.

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Tadalafil helps relax the muscles and increases blood flow to certain body parts, including the penis, assisting men to attain and maintain an erection.

Tadalafil belongs to the Phosphodiesterase Type 5 (PDE5) inhibitors group of medicines. 

When you take Tadalafil, it inhibits the PDE5 enzyme, which helps increase the levels of cyclic Guanosine Monophosphate (cGMP) in the body. 

Elevated cGMP levels relax the blood vessels, allowing improved blood flow to the penis and facilitating erections.

Factors affecting Tadalafil’s duration

Taking medicineSource: AndreyPopov_from_Getty_Images
Taking Tadalafil pill

Tadalafil differs from other Phosphodiesterase Type 5 (PDE5) inhibitors due to its notably extended duration of action. 

According to the National Library of Medicine, in contrast to Viagra, Tadalafil has the potential to remain efficacious for 36 hours after just one dose.

To get the most out of Tadalafil and ensure its maximum effectiveness, consider the following tips.

Recommended read: Optimize Tadalafil use for peak results and unlock the full potential. Learn more in our guide – How to Get Maximum Effect From Cialis?


Higher doses of Tadalafil tend to have a more prolonged effect. Tadalafil is available in doses of 2.5, 5, 10 and 20 mg. 

It is also available in a 40 mg dose for those having Pulmonary Arterial Hypertension (PAH). It’s crucial to follow your doctor’s instructions regarding Cialis dosage.

Before taking Tadalafil it is essential to consult your doctor for the right dosage.

To know more about Tadalafil’s dosage pattern read our article Your Ultimate Guide to Tadalafil Dosage


Each individual’s metabolism works differently. 

Some people may metabolize Tadalafil more quickly, leading to a shorter duration of action. In contrast, others may experience its effects for an extended period.

Other medications

Certain medications can interact with Tadalafil and affect its duration. Medicines like Nitrates, Alpha-Blockers, etc., can interact with Tadalafil and lead to potential Tadalafil side effects.

You must inform your doctor about every other medicine you take to ensure they won’t interfere with Tadalafil’s effectiveness.


When addressing the challenges of ED, Tadalafil has proven to be a popular and effective medication.

If you’re wondering “How long does Tadalafil last”, the answer lies in its remarkable duration of action. 

Typically, Tadalafil remains active in the body for up to 36 hours, providing a longer opportunity for sexual activity than other ED pills. 

Factors such as dosage, metabolism, and potential interactions with other medications can influence Tadalafil’s duration. 

Consulting your doctor can help you choose the proper treatment and maximize the benefits of Tadalafil, ultimately treating your ED.

Frequently Asked Questions

Tadalafil 5 mg how long does it last?

Tadalafil has the longest duration of action compared to any PDE5 inhibitor, lasting up to 36 hours and sometimes longer.

How long for Tadalafil to work?

Tadalafil often begins to work in 30 to 60 minutes of taking it. If you take it for ED, you need to feel sexually aroused for it to work.

How long does Tadalafil take to work?

Tadalafil has the longest half-life of any PDE5 inhibitor, lasting up to 36 hours and sometimes longer.

How long does 20 mg of Tadalafil work?

It is not advisable to consume the 10 mg or 20 mg tablets on a daily basis due to the possibility of prolonged effects beyond the 24-hour timeframe.

Can I take 2 tablets of Tadalafil 5mg?

If your doctor advises you to take Tadalafil just as needed for ED, the usual starting dose is 10 mg before sexual activity. 

If this dose does not work for you, your doctor may prescribe two 5 mg Cialis tablets at once.

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