Erectile Dysfunction can be effectively treated with Tadalafil.
It’s a Phosphodiesterase type 5 (PDE5) inhibitor that keeps your blood vessels dilated.
Tadalafil increases blood flow to your penis’ soft tissue, leading to an erection.
Tadalafil has a substantially more extended period of effectiveness than other PDE5 Inhibitors.
This makes Tadalafil a better option to treat your ED.
However, just like the majority of other medicines, Tadalafil also might have some unfavorable interactions.
Tadalafil may interact with other pills, vitamins, herbs, diseases, or food items you may be consuming.
These interactions can change the way Tadalafil work. This, in turn, leads to specific side effects.
Thus, it is recommended that you inform your doctor about all prescription, over-the-counter medications you are taking before taking Tadalafil.
In this article, you will learn about Tadalafil interactions in detail.
Tadalafil Interactions with Other Medicines
If you use any other medications, vitamins, or herbal supplements, Tadalafil oral pills may interact with them.
When a substance modifies how a medication functions, this is known as interaction.
This might be hazardous or stop the medication from working properly.
Nitrates, GC stimulators, Alpha-blockers, and other medications can all interact with Tadalafil.
Doctors may not recommend Tadalafil in combination with the following medicines due to the possibility of side effects.
Guanylate Cyclase (GC) Stimulators
The medications used to treat Pulmonary Arterial Hypertension are known as Guanylate cyclase (GC) stimulators, such as Vericiguat and Riociguat.
Tadalafil and GC stimulants both have the potential to reduce blood pressure.
Taking Tadalafil along with a GC stimulator may result in even lower blood pressure.
As a result, doctors are unlikely to prescribe Tadalafil in conjunction with GC stimulants.
Nitrate is a vasodilator used to treat or prevent anal fissures, Angina, heart failure, and Hypertension.
If you use Tadalafil with Nitrates, your blood pressure may decrease significantly.
Fainting and lightheadedness can result from a sudden drop in blood pressure.
In extreme circumstances, it might result in a heart attack or stroke.
According to studies, Alpha-blockers like Doxazosin or Tamsulosin are used to treat Benign Prostate Hyperplasia (BPH) or high blood pressure.
Your blood pressure may drop too low when using Tadalafil along with Alpha-blockers.
This might cause fainting or dizziness.
Tadalafil’s working can be impacted by other medications, which may change how Tadalafil functions.
- HIV Protease inhibitors like Fosamprenavir
- Azole antifungals like Itraconazole and Ketoconazole
- Macrolide antibiotics like Clarithromycin and Erythromycin.
Other PDE5 Inhibitors
Tadalafil belongs to a group of medications known as PDE5 inhibitors. Tadalafil and other medications from this group can reduce blood pressure.
Combining Tadalafil with other medicines in the same family, such as Sildenafil, Vardenafil, and Avanafil, might increase the risk of low blood pressure even more.
As a result, serious side effects may occur.
Certain antibiotics, such as Erythromycin and Rifampin, may stop your body from metabolizing Tadalafil.
As a result, your body may have more Tadalafil than usual.
Your chance of experiencing adverse side effects from Tadalafil may rise if you have a high concentration of Tadalafil in your body.
Your body may break down Tadalafil faster than usual if you use particular antiseizure medications like Carbamazepine and Phenobarbital.
As a consequence, your body may have less Tadalafil than usual. This might reduce the ability of Tadalafil to treat your Erectile Dysfunction effectively.
Tadalafil Interactions with Food
Consuming Tadalafil, along with alcohol and grapefruit or grape juice, can lead to serious side effects.
Dizziness, fainting, lightheadedness, flushing, headaches, and palpitations are some symptoms you may encounter more frequently after combining Tadalafil with alcohol or grapefruit.
When using Tadalafil, avoid drinking alcohol.
Tadalafil raises the risk of extremely low blood pressure when alcohol is consumed along with it.
Call your doctor immediately if you experience dizziness, lightheadedness, or blurred vision.
Grapefruit or Grape Juice
According to a research paper published in NCBI, grapefruit juice may enhance the body’s plasma exposure to Tadalafil.
This may prevent Tadalafil from being metabolized.
Consequently, Tadalafil’s adverse effects will increase.
Tadalafil Interaction with Diseases
The risk of interactions with Tadalafil may rise due to several diseases and other circumstances.
If you have a history of heart diseases, blood-related disorders, kidney or liver disease, etc., consult your doctor before using Tadalafil.
The following health issues or conditions might affect how Tadalafil works:
Heart Disease or Stroke
If you have a heart condition or have recently suffered a stroke, doctors usually won’t prescribe Tadalafil.
Additionally, Tadalafil is not advised for those who have issues like these:
- Untreated high or low blood pressure
- Chest discomfort
- Untreated and irregular heart rhythm
Blood Cancers or problems with Blood Cells
If you have Blood Cancer (such as Leukaemia and Multiple Myeloma), inform your doctor before using Tadalafil.
Also, tell them if you suffer from blood cell conditions, such as Sickle Cell Anemia.
Your risk of Priapism might rise as a result of these situations.
Priapism: It is a condition in which the penis maintains an erection for an extended time without suitable stimulation.
Kidney or liver diseases
Before using Tadalafil, let your doctor know if you have a liver or renal condition.
Failures of the kidneys and the liver are two such diseases that may interact with Tadalafil.
Tadalafil is a safe and effective treatment for Erectile Dysfunction and may be the best option for you.
Additional factors must also be considered, such as potential side effects and medication interactions.
Tadalafil causes side effects when it interacts with a number of different medications and food items.
Tadalafil tablet’s label might have colored stickers on the label that describe an interaction.
Ask your doctor to explain this information if you need clarification.
Frequently Asked Questions
What can you not take with Tadalafil?
When using Tadalafil, avoid drinking large amounts of alcohol. Additionally, avoid consuming grapefruit or grapefruit juice while taking this medication.
What drugs should not be taken with Tadalafil?
Tadalafil and other medications, such as Nitrates, Azole antifungals, Alpha-blockers, Macrolide antibiotics, other PDE5 inhibitors, and others, should not be consumed together.
Can you drink alcohol with Tadalafil?
No. When using Tadalafil, restrict the consumption of alcohol.
Alcohol consumption in excess can raise your risk of experiencing headaches or dizziness, speed up your heartbeat, or reduce your blood pressure.
Should I avoid certain foods while taking Tadalafil?
Yes. While using Tadalafil, avoid eating grapefruit or drinking grapefruit juice.
Grapefruit and grapefruit juice may affect how much Tadalafil is absorbed in your body.
Is taking Tadalafil harmful to your heart?
Yes. People with cardiac issues may face substantial adverse effects while consuming Tadalafil.
Do not use Tadalafil if you also take Riociguat or any Nitrate medication frequently prescribed to treat Angina (chest pain).
Is Tadalafil affected by food?
Yes. Tadalafil may be taken before or after meals.
For quick results, it is better to take Tadalafil on an empty stomach.
A high-fat meal could slow down tadalafil’s effects.
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