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Vardenafil vs Tadalafil: A Comprehensive Guide

Julian Carter


Vardenafil vs Tadalafil: Which is better

Erectile Dysfunction (ED) is a common sexual issue among aging men. It leads to an inability in attaining and maintaining a satisfactory erection.

Vardenafil and Tadalafil are two common medications prescribed for Erectile Dysfunction. Both these medications are highly effective and trusted by certified doctors. However, given their similarities, it can be confusing to determine which pill is ideal for you.

This article discusses the differences between Vardenafil and Tadalafil to help you choose the right medication.

Vardenafil vs Tadalafil: Working

Vardenafil and Tadalafil have similar action mechanisms to treat Erectile Dysfunction (ED). 

Both these medications fall in the category of Phosphodiesterase Type-5 (PDE-5) inhibitors that block PDE-5 enzymes, thereby restoring the levels of cyclic Guanosine Monophosphate (cGMP). This results in relaxed penile blood vessels which improve blood flow. 

However, there is a slight difference in their working. Vardenafil, commonly called Levitra, has a more targeted action on the PDE5 enzyme. This makes it more suitable for some individuals. Tadalafil (Cialis) on the other hand, allows room for spontaneity in sexual experiences due to its long-lasting action. 

Avoid buying medications from gas stations as they are often fake or counterfeit.

Comparing onset and duration of action

Vardenafil has a faster onset of action as compared to Tadalafil. It usually starts showing effect within 30 minutes after ingestion and lasts for around 5-7 hours. 

In contrast, Tadalafil takes around 30 to 60 minutes to start working. However, it lasts for a significantly longer duration of up to 36 hours. Hence, it allows for more spontaneity and flexibility in sexual activity. 

If you experience prolonged erections or Priapism with any of these medications, consult a doctor immediately.

Comparing Side Effects

A man suffering from headache
A man suffering from headache

Vardenafil and Tadalafil are generally safe and well-tolerated. They are FDA-approved for treating ED. 

However, they may cause side effects in some individuals. Common side effects of Vardenafil and Tadalafil include headaches, nasal congestion, flushing, indigestion, and dizziness. Medicines like Tadalafil may also lower your blood pressure. Therefore, they should not be taken with nitrates or alpha-blockers. 

Read: Tadalafil Side Effects And How To Avoid Them to explore all the side effects of Tadalafil in detail to make informed choices. 

A Complete Comparison between Vardenafil and Tadalafil

Factors Vardenafil Tadalafil 
Drug classPDE5 inhibitorPDE5 inhibitor
Medicine typeGeneric Generic 
Onset of action15-30 minutes 30-60 minutes 
Duration of action5-7 hours 36 hours
Side effects headaches, nasal congestion, flushing, cough, and dizziness, low blood pressure etc.headaches, nasal congestion, flushing, indigestion, and dizziness, low blood pressure.


Vardenafil and Tadalafil are both effective medications for Erectile Dysfunction (ED).  

They have a similar mechanism of action but with some differences in onset of action, duration, and dosing. Vardenafil acts in about 30 minutes and lasts for 5-7 hours. Whereas Tadalafil works in 30-60 minutes and lasts for up to 36 hours.

The choice between Tadalafil and Vardenafil depends on individual preferences and needs. In rare cases, these medications may lead to side effects such as headache, flushing, or dizziness.

As with any other medication, it is vital to consult a doctor before starting treatment with Vardenafil vs Tadalafil. 

Frequently Asked Questions

What is the strongest ED pill?

The strongest Erectile Dysfunction (ED) pill is subjective and depends on individual response, but many consider Sildenafil (Viagra) and Tadalafil (Cialis) as top choices due to their high efficacy rates. Tadalafil is notable for its prolonged effect lasting up to 36 hours. 

How strong is Vardenafil?

Vardenafil is quite potent, typically prescribed in 5 mg, 10 mg, or 20 mg doses. It effectively treats erectile dysfunction by targeting the PDE5 enzyme.
However, the strength of Vardenafil may differ for each individual based on various factors.

Is Vardenafil stronger than Viagra?

Vardenafil (Levitra) and Viagra (Sildenafil) are similar in strength, but Vardenafil may be more potent in smaller doses and can work slightly faster for some individuals. The effectiveness varies per person, so one might work better than the other.

How to cure ED permanently?

To completely cure ED, it is important to consult a certified doctor. They may prescribe ED pills and other treatment methods after diagnosing your condition.

Which is the best: Sildenafil, Tadalafil, or Vardenafil?

The best choice among Sildenafil, Tadalafil, and Vardenafil depends on individual preferences and needs. All three are effective in treating ED. However, Tadalafil’s longer duration of action may be preferred by some for its flexibility. 

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