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Vardenafil vs Tadalafil: A Closer Look At Similarity and Differences

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Written by- Julian Carter

Vardenafil and Tadalafil are two of the most popular medications for treating Erectile Dysfunction (ED). 

They belong to a group of medicines called Phosphodiesterase Type type 5 (PDE5) inhibitors. 

PDE5 inhibitors relax the blood vessels in the penis and allow increased blood flow. This mechanism facilitates an erection. 

While both Vardenafil and Tadalafil share some similarities, they also have differences.

This article will compare Vardenafil vs Tadalafil, the working mechanisms, differences, side effects, etc.

Vardenafil vs Tadalafil: how do they work

Vardenafil and Tadalafil work similarly by inhibiting the PDE5 enzyme to treat Erectile Dysfunction.

They increase the blood flow to the penis during sexual stimulation.

However, there is a slight variation in the way in which they interact with the body. 

Vardenafil, commonly called Levitra, has a more targeted action on the PDE5 enzyme. It makes Vardenafil more suitable for some individuals. 

Tadalafil, or Cialis, on the other hand, allows for spontaneity in sexual experiences due to its long-lasting action.

How are Vardenafil and Tadalafil different

Both of these medicines are PDE5 inhibitors and serve the same purpose. However, they have some differences in their characteristics. 

According to Healthline, Vardenafil is known to work faster than Tadalafil. It means Vardenafil may start working sooner after ingestion. 

Additionally, Vardenafil is typically taken as needed, while Tadalafil is available in daily and as-needed formulations. 

The duration of action for Vardenafil is around 4 to 5 hours. 

On the other hand, Tadalafil can last up to 36 hours. That’s why it has the nickname “the weekend pill.”

Which is stronger: Tadalafil or Vardenafil

The potency of Vardenafil and Tadalafil is quite similar. Both of these medications are effective in the treatment of ED

The choice between the two depends on individual preferences, bodily responses, and underlying health conditions. 

It is crucial to consult to determine the most suitable option between Vardenafil and Tadalafil based on specific needs and medical history.

Onset of action and duration

As mentioned earlier, Vardenafil has a faster onset of action. It usually starts showing effect within 30 minutes after taking it. It lasts for around 5-7 hours.

In contrast, Tadalafil takes around 30 to 60 minutes to start working. 

However, Tadalafil lasts for a significantly longer duration, from 4 hours to 36 hours. 

It allows for spontaneity and flexibility in sexual activity. 

Side effects of Tadalafil and Vardenafil

A man suffering from headacheSource: SIphotography
Headache is a minor side effect of consuming ED Medication

Vardenafil and Tadalafil are generally safe and well-tolerated. They are FDA-approved for treating ED. 

However, they may cause side effects in some individuals.

Common side effects of Vardenafil and Tadalafil include headaches, nasal congestion, flushing, indigestion, and dizziness. 

Medicines like Tadalafil may also lower your blood pressure. So they should not be taken with nitrates or alpha-blockers. 

Recommended read: Explore the side effects of Tadalafil in detail to make informed choices – Tadalafil Side Effects And How To Avoid Them.

If you experience severe side effects, such as Priapism (a prolonged and painful erection) or sudden vision loss, seek medical attention immediately.

Vardenafil vs Tadalafil: price and availability

The availability and price of Vardenafil and Tadalafil can vary depending on the country of purchase and the brand. 

Mostly, generic versions of these medications are more affordable than their brand-name counterparts. 

These medications are not available over the counter. It means you can buy them only through a doctor’s prescription.

Purchasing them from reputable pharmacies or licensed online platforms is essential to ensure safety and efficacy.

Where to buy Vardenafil and Tadalafil

Vardenafil and Tadalafil are prescription medications. You must always buy them from licensed healthcare pharmacies. 

You should always avoid purchasing these drugs from unverified sources or over the counter. Over-the-counter ED pills may contain hidden or illegal ingredients that pose significant health risks.

It is important to consult a doctor to get a prescription and guidance on where to buy these medications safely.

If you plan on buying Vardenafil and Tadalafil online, you should always verify the credibility of the online pharmacy. 

Looking for a safe and credible online pharmacy to purchase

Buy your ED medicines from one of the best online pharmacies today: GoodRxMedicine

Sildenafil vs Tadalafil vs Vardenafil

According to research, PDE-5 inhibitors have long been effective in the treatment of ED.

Apart from Vardenafil and Tadalafil, there is another well-known PDE5 inhibitor called Sildenafil. It is the active ingredient in Viagra.

Sildenafil also works similarly by increasing blood flow to the penis. It helps to help achieve and maintain an erection

The main differences between these medications are their onset of action, duration, and dosing schedule. 

Sildenafil has a quicker onset of action. But it has a shorter duration compared to the other two. Tadalafil can last the longest, up to 36 hours, while Sildenafil and Vardenafil last around 4-6 hours.

Recommended read: For a better and more detailed comparison between the three ED pills, check out – Cialis vs Viagra vs Levitra: Which is Better?

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Do they have any interactions

A doctor checking the blood pressure of a patient
Mixing medications can lead to low blood pressure

Medical research suggests that Vardenafil vs Tadalafil, and Sildenafil should not be taken with Nitrates. 

This combination can lead to a dangerous lowering of blood pressure. These medications may also interact with other medicines.

Vardenafil and Tadalafil interactions can be very harmful.

So it’s crucial to inform your doctor about all your medications. It will help avoid potential interactions and health hazards.

Factors Vardenafil Tadalafil 
Drug classPDE5 inhibitorPDE5 inhibitor
Medicine typeGeneric Generic 
Onset of action15-30 minutes 30-60 minutes 
Duration of action5-7 hours 4-36 hours
Side effects headaches, nasal congestion, flushing, cough, and dizziness, low blood pressure etc.headaches, nasal congestion, flushing, indigestion, and dizziness, low blood pressure.

Summing up

Vardenafil and Tadalafil are both effective medications for Erectile Dysfunction.  

They have a similar mechanism of action but with some differences in onset of action, duration, and dosing. 

The choice between Tadalafil and Vardenafil depends on individual preferences and needs. 

As with any other medication, it is vital to consult a doctor before starting treatment with Vardenafil vs Tadalafil. 

Remember, you must follow the prescribed dosage and promptly report any side effects.

Frequently Asked Questions

Which is the best: Sildenafil, Tadalafil, or Vardenafil?

There is nothing like the best medicine. The best choice among Sildenafil, Tadalafil, and Vardenafil depends on individual preferences and needs. All three are effective in treating ED. However, Tadalafil’s longer duration of action may be preferred by some for its flexibility. 

What is stronger: Tadalafil or Vardenafil?

The potency of Tadalafil and Vardenafil is quite similar. Both medications have shown efficacy in treating ED. The choice between the two depends on you and the doctor’s advice.

How long does Vardenafil last?

Vardenafil’s effects typically last for about 4 to 5 hours after taking it. During this time, a man may find it easier to achieve and maintain an erection during sexual stimulation.

What is better than Tadalafil?

Tadalafil is an effective and popular medication for ED. However, if you don’t find it suitable, you should consult your doctor. They may recommend other PDE5 inhibitors like Vardenafil or Sildenafil. 

Which ED medication is the safest?

Vardenafil, Tadalafil, and Sildenafil are safe when you take them in the correct dosage as the doctor prescribes. However, the safety of each medication varies depending on individual health conditions. Discussing your medical history with your doctor to find the safest option for you is crucial.

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