Erectile Dysfunction (ED) is a common sexual condition in men, with around 322 million men dealing with the issue globally as of 2025. While it can lower confidence and feel concerning, effective and safe medications are readily available today for the treatment.
Among the most suggested ED medicines, Stendra and Viagra stand out for how effectively they enhance blood flow to help get and maintain firm erections. Both belong to the same medication class, but differ in their active ingredient, duration, cost, and onset of action. Stendra, containing Avanafil, is costlier but faster, while Viagra, with Sildenafil, is cheaper but takes more time to show its effectiveness.
This article will cover Stendra vs Viagra in depth, exploring such key differences, which also include off-label and approved uses, strengths available, and interaction with alcohol. We will also suggest which medication can be more suitable for your needs, helping you make an informed decision.
Viagra vs Stendra: Key differences at a glance
As mentioned before, both of these prescription-only medications are used for addressing Erectile Dysfunction in men. The answer to which pill to prefer lies in understanding their core differences. The following are the key distinctions between Stendra and Viagra. Comparing them side by side will provide a clear picture of their overall benefits in relation to one another.
| Comparable factors | Stendra | Viagra |
| Active ingredient | Avanafil | Sildenafil |
| FDA approval | FDA-approved for ED | FDA-approved for ED |
| Uses | On-label used for ED treatment in adult men Off-label used for Raynaud’s phenomenon (affects blood flow to the fingers and toes, causing visible color changes) | On-label used for ED treatment in adult men Off-label used for Raynaud’s phenomenon and Female Sexual Arousal Disorder (FSAD) |
| Onset of action | 15-30 minutes | 30-60 minutes |
| Duration of effect | Around 4-6 hours | Approximately 4-5 hours |
| Side effects | Headache, back pain, indigestion | Headache, blurred vision, dizziness |
| Strengths available | 50, 100, 200 mg | 25, 50, 100 mg |
| Dosage | Typical starting dosage is 100 mg | Typical starting dosage is 50 mg |
| Affordability | More expensive due to limited availability of its generic versions | Less costly with numerous generic versions available |
| Food interaction | Minimal delay | High-fat meals can delay absorption |
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Active ingredient and medication class
Stendra contains Avanafil, while Viagra contains Sildenafil Citrate as an active ingredient. Both ingredients belong to the Phosphodiesterase Type 5 (PDE-5) inhibitor class, with Avanafil being a newer-generation inhibitor.
In terms of their working mechanism, both work similarly by blocking the PDE-5 enzyme to relax the blood vessels. This activity increases blood flow into the penis and enables an erection. However, Stendra is considered more selective for this enzyme than Sildenafil. This means it targets the PDE-5 enzyme more precisely than Sildenafil does.
Regulation and uses
The FDA approved Stendra in April 2012 and Viagra in March 1998 for ED treatment.
Approved uses include:
- Stendra: First oral medicine for ED that is marketed with an on-demand label. It means it is taken only when needed, which is shortly before a sexual interaction, rather than on a fixed schedule or daily basis.
- Viagra: First oral medicine to be approved for ED in adult men. Moreover, the salt of this tablet, Sildenafil, under a different brand name, Revatio, is also approved to treat Pulmonary Arterial Hypertension (PAH).
Off-label uses are as follows:
- Stendra: Off-label, some doctors can prescribe it to address Raynaud’s phenomenon.
- Viagra: It is also off-label prescribed for Raynaud’s phenomenon. Additionally, it can enhance sensations in women by increasing blood flow to the genitals, potentially treating FSAD.
Viagra can be a better choice for men looking for an ED medication with a longer approval history and a broad range of uses. On the other hand, for an on-demand option, Stendra can be the right choice.
Effectiveness and onset of action
Viagra takes 30-60 minutes to show effects post-intake. In contrast, Avanafil is marketed as an on-demand pill due to its rapid onset of action, which occurs within 15 to 30 minutes. This makes it one of the fastest-acting tablets for improving erections. Therefore, Stendra is more convenient for spontaneous sexual activity.
Additionally, Viagra remains effective for 4 to 5 hours, whereas Stendra is found to sustain its effectiveness for around 6 hours after administration. Note that both medications need sexual stimulation to work.
Viagra vs Stendra dosage
The starting dose of Sildenafil and Avanafil is usually 50 mg and 100 mg, respectively. However, a doctor will suggest the appropriate dosage strength after examining the patient’s health status and the severity of the ED. Based on toleration and effectiveness, a doctor can adjust the dosage as needed. Note that greater strength can increase the risk of side effects.
Sildenafil Citrate tablet is usually taken 30-60 minutes before planned sexual activity. However, the FDA-approved label states 30 minutes to 4 hours. In contrast, Avanafil can be taken 15 minutes before sexual interaction. It is strongly advised not to exceed one pill of either medicine within a 24-hour period.
Stendra vs Viagra side effects
Like all PDE-5 inhibitors, Sildenafil and Avanafil can trigger some temporary and mild to moderate side effects. They subside as the body adjusts to the dosage. However, it is crucial to seek medical assistance if symptoms persist for an extended period.
As discussed before, since Avanafil is a newer and more selective medication, it is less likely to trigger common unwanted effects like:
- Sore throat
- Muscle pain
- Congested nose
- Headache
- Redness of the neck and face
On the other hand, side effects of Viagra are as follows:
- Dizziness
- Nausea
- Headache
- Upset stomach
- Vision changes, like blurred vision, sensitivity to light, or seeing a blue tint
Also Read: To understand tips to control side effects caused by Viagra, read How to Get Rid of Viagra Side Effects?
Sildenafil vs Avanafil cost and strengths
Sildenafil-containing tablets are available in strengths of 25 mg, 50 mg, and 100 mg, whereas Avanafil is marketed in higher strengths of 50 mg, 100 mg, and 200 mg.
Since the active ingredient of Viagra is now widely available as a generic medicine, often referred to as Generic Viagra, it is much cheaper than Stendra, which is typically available only as a brand version. The cost is $4 for a generic pill of Sildenafil, whereas it is $52 to $80/pill for Avanafil.
Men with cost issues can choose Sildenafil, as it’s more affordable. For a stronger dose option, Avanafil is suitable, as its highest dosage is 200 mg.
Effect of food and alcohol
The effectiveness of Avanafil is mildly affected when taken on a full stomach. Whereas several studies claim that high-fat meals can delay the absorption of Sildenafil, resulting in a delayed effect.
Furthermore, alcohol intake can increase the risk of side effects and trigger a severe drop in blood pressure in combination with both of these ED tablets. However, Avanafil is less sensitive to alcohol.
Avanafil can be considered by those who experience discomfort taking medication on an empty stomach, since its performance is not significantly affected by meals.
How to choose between Viagra and Stendra
Although selection between the two depends on lifestyle, personal preferences, and a professional recommendation, the following points can be considered to make an informed choice:
- Choose generic Sildenafil (or Viagra) if cost is an issue. It is also a good option for those who prefer low doses of ED tablets or are indulging in a planned intimacy act.
- Choose Stendra for a fast-acting option or when sexual activity is not pre-planned. It is also ideal for men who are comfortable with its high cost or have consumed alcohol before sexual interaction.
One must consult a doctor for safety and proper dosage, particularly those who have any underlying health issues like heart conditions or those on nitrates.
Conclusion
When comparing Stendra vs Viagra, both medications are used as effective ED treatment. Viagra continues to be the gold standard treatment, offering both efficacy and affordability proven through years of use. Stendra, a newer-generation PDE-5 inhibitor, offers a reduced risk of side effects, such as headache and dizziness, and a rapid onset of action.
Some other key differences include the duration of effectiveness, with Avanafil lasting longer, up to 4-6 hours. Heavy meals and alcohol intake have a greater impact on Sildenafil’s absorption than Stendra.
Always consult a doctor before taking the ED medication. While choosing between the two will depend on personal needs and body tolerance, one can select Stendra for fast effects and Viagra for its low cost.
Frequently Asked Questions
Is Cialis stronger than Viagra?
No, Cialis isn’t stronger than Viagra, as both the ED medications are considered equally effective. Cialis (Tadalafil) can last for 36 hours and take around 2 hours to work. On the other hand, Viagra (Sildenafil) generally lasts for 4-5 hours and acts fast within 30-60 minutes.
Does Stendra affect blood pressure?
Yes, Stendra can affect blood pressure by triggering a drop in blood pressure levels (Hypotension) through its ability to dilate blood vessels. For healthy men, this effect is generally mild and not a concern. However, individuals with existing heart issues should practice caution and consult a doctor.
Why is my 50 mg Viagra not working?
If your 50 mg Viagra isn’t working, it could be due to low dosage and incorrect timing of intake. It must be taken 30-60 minutes before sexual activity. Any underlying health issue or interaction with alcohol and a heavy meal can also impact the effectiveness of medicine.
What is the peak time of Avanafil?
Studies report that the peak time (Tmax) of Avanafil is 30-45 minutes after intake, when its concentration is the highest in the bloodstream. The medicine typically starts working within 15-20 minutes and remains effective for 6 hours.
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