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Is It Effective to Take Paroxetine For Premature Ejaculation

Gina Walters


paroxetine for premature ejaculation

Premature Ejaculation (PE) can cause distress and affect your quality of life.  

It is the most prevalent male ejaculation condition and can affect men of any age. 

Premature Ejaculation can be prevented by certain techniques and medications. One of them is Paroxetine.

Paroxetine is an antidepressant medication and a Selective Serotonin Reuptake Inhibitor that raises serotonin in the brain. 

It is commonly used to treat Depression, OCD, panic attacks, Post-Traumatic Stress Disorder (PTSD), and Anxiety. 

Many medical researchers have discovered that the medication can also help delay ejaculation. 

Doctors often prescribe Paroxetine off-label to treat Premature Ejaculation. 

Read this article to find out if Paroxetine is effective for Premature Ejaculation.

Is Paroxetine effective in treating PE

Males suffering from Premature Ejaculation can benefit from a single dose of Paroxetine taken before scheduled intercourse.

It may also be beneficial to take Paroxetine daily for some time.

Paroxetine is one of the SSRIs that increases 5-HT levels and delays ejaculation. 

Paroxetine seems to be the most effective medication for PE approved for use in the United States.

It usually takes 5 to 10 days for these medications to begin working. For results, it may take 2 to 3 weeks of treatment.

Can you take Paroxetine for Premature Ejaculation

Man with anxietySource: RyanKing999

Paroxetine is an SSRI medicine FDA-approved for treating Depression, OCD, Anxiety, and PTSD.

The FDA has not approved Paroxetine for PE. However, doctors recommend taking it off-label due to its effectiveness in treating PE.

Paroxetine boosts serotonin levels, which aids in delaying ejaculation.

It prevents the brain from lowering the available supply of serotonin. 

Paroxetine can effectively treat Premature Ejaculation symptoms by delaying ejaculation, as supported by a study on nearly 100 men.

Research suggests that Paroxetine is more effective than other SSRIs and PDE-5 inhibitors in treating Premature Ejaculation.

How long does Paroxetine take to work for Premature Ejaculation

Serotonin is an essential factor in ejaculatory response. 

High serotonin levels usually cause a delay in ejaculation.

As a result of the enhanced serotonin activation caused by Paroxetine, you should have longer durations until ejaculation. But does it work?

A study on over two-thirds of men who experienced delayed ejaculation revealed that Paroxetine is an efficient medicine in treating PE.

Approximately 8% of individuals experienced adverse effects like reduced sexual satisfaction and decreased sex drive, while the majority encountered no side effects.

The side effects of Paroxetine

NauseaSource: wutzkoh

Paroxetine oral tablets can produce drowsiness and impair your ability to make judgments, think clearly, or respond fast. 

Paroxetine may produce various side effects.

The following are the most prevalent side effects of Paroxetine oral tablets:

  • Drowsiness
  • Lack of sleep
  • Nausea
  • Stress 
  • Delayed Ejaculation
  • Lower sexual desire
  • Impotence
  • Dry mouth
  • Constipation
  • Yawning

If the side effects are minor, they should fade away within a few days or weeks. If they get more severe or do not go away, consult with your doctor.

Individuals should avoid driving, using heavy machinery, or performing other duties that require alertness until they have determined how this medicine affects them.

Sertraline vs Paroxetine: Premature Ejaculation

Selective serotonin reuptake inhibitors (SSRIs) like Sertraline and Paroxetine significantly delay ejaculation, making sex more enjoyable. 

Doctors can prescribe either Paroxetine or Sertraline for Premature Ejaculation

The typical daily dose for Paroxetine is 20 mg, while for Sertraline, it is 50 mg

Both come in tablet and liquid forms. 

Using Sertraline may increase suicidal thoughts and dangerous behaviors, especially in younger people. Consult your doctor if you have any worries.

The main differences between Paroxetine and Sertraline are documented in the table below:

Drug classSelective Serotonin Reuptake Inhibitor (SSRI)Selective Serotonin Reuptake Inhibitor (SSRI)
Formulations of the drugTabletsExtended-release tablets Tablets Solutions
Standard dosage10-60 mg daily50-200 mg daily
Recommended forBest for adults and children of seven years old Best for adults and children of six years old 


PE can be a source of frustration and distress in an individual’s sexual life. 

Premature Ejaculation (PE) primarily stems from psychological factors such as stress, Depression, Anxiety, and concerns about sexual performance.

However, it is necessary to note that effective treatments are available to cure PE.

Paroxetine is one antidepressant that doctors may recommend for Premature Ejaculation.   

It is an  SSRI  that can assist in controlling PE symptoms. 

It is necessary to know about the side effects of Paroxetine to treat PE more effectively.

The most common side effects of Paroxetine are nausea, drowsiness, and Serotonin Syndrome.

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Frequently Asked Questions

Does Paroxetine help with Premature Ejaculation?

Paroxetine is a type of medication known as Selective Serotonin Reuptake Inhibitor (SSRI) that is primarily used to treat Depression. It can also treat Premature Ejaculation (PE) as a side effect.

Can Paroxetine be used for Premature Ejaculation?

Paroxetine is an effective treatment for Premature Ejaculation. Apart from its primary use in managing mood disorders, Paroxetine is sometimes prescribed off-label for treating Premature Ejaculation.

Does Paroxetine cure Premature Ejaculation?

Paroxetine cannot cure Premature Ejaculation, but it may help treat its symptoms.

What is the recommended dose of Paroxetine in Premature Ejaculation?

A dosage of 20 mg of Paroxetine has been found to effectively treat PE. Taking Paroxetine daily or a few hours before sexual activity can treat PE.

How to take Paroxetine for Premature Ejaculation?

An individual should take Paroxetine once daily in the morning. Taking it with a meal is advisable to prevent any potential stomach discomfort.

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