Votrient 400 Mg

Medically Reviewed by

Dr. Akanksha Kaushal

Dr. Akanksha, Pharm-D

Dr. Akansha is a licensed Clinical Pharmacologist with extensive expertise in pharmacovigilance, prescription analysis, drug information, and safety. She's a dedicated educator and avid learner. Dr. Akansha also reviews medical content on GoodRxMedicine, ensuring accurate pharmaceutical information is accessible to all.

Written by

Julian Carter

Julian Carter

Julian, an MBA in Pharmaceutical Management, brings a dynamic blend of expertise and impact with his contributions at GoodRxMedicine. His dedication and innovative spirit continue to shape a brighter future in pharmaceutical management.

What is Votrient 400?

Votrient 400 is a prescription medication containing 400 mg of Pazopanib, a tyrosine kinase inhibitor. It's used to treat advanced Renal Cell Carcinoma (kidney cancer) and soft tissue sarcoma. This targeted therapy works by inhibiting multiple proteins that promote cancer cell growth and tumor blood vessel development.

Novartis is the manufacturer of Votrient 400 mg. As a specialized oncology medication, it offers targeted treatment for specific types of cancer that have not responded to other therapies.

Uses of Votrient 400

Votrient 400 mg tablets are primarily prescribed for:

• Advanced Renal Cell Carcinoma (RCC): It's used as a first-line treatment for people with advanced kidney cancer or after cytokine therapy has failed.
• Advanced Soft Tissue Sarcoma (STS): Votrient is prescribed for patients who have received prior chemotherapy for specific types of soft tissue sarcoma, excluding adipocytic STS and gastrointestinal stromal tumors.

Pazopanib tablets provide an oral treatment option inhibiting angiogenesis (forming new blood vessels), which is crucial for tumor growth and metastasis. This medication offers hope for patients with limited treatment alternatives for these challenging cancers.

Working and benefits of Pazopanib

Votrient 400 mg contains Pazopanib Hydrochloride, which functions as a multi-tyrosine kinase inhibitor. It works by blocking several enzymes (kinases) that signal cancer cells to grow and divide uncontrollably while also inhibiting the development of new blood vessels that feed tumors.

The medication specifically targets vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3), platelet-derived growth factor receptors (PDGFR-α and PDGFR-β), fibroblast growth factor receptor (FGFR), and c-Kit receptor. By inhibiting these multiple pathways simultaneously, Pazopanib delivers a comprehensive approach to fighting cancer.

Key benefits of Pazopanib 400 mg include:

• Prolonged progression-free survival: Clinical studies show significant extension in time before cancer progresses compared to placebo.
• Tumor shrinkage: Patients with Renal Cell Carcinoma experience meaningful tumor reduction.
• Oral administration: Convenient tablet form allows treatment at home rather than requiring hospital visits for infusions.
• Targeted mechanism: Selectively attacks cancer cells, potentially causing fewer side effects than traditional chemotherapy.
• Established efficacy: Demonstrates effectiveness in patients who have limited treatment options, including those who have not responded to previous therapies.

Votrient offers a powerful treatment option for patients with specific advanced cancers by disrupting multiple processes essential for tumor survival and growth.

Dosage and how to take Votrient 400

Here's how to take Votrient tablet safely and effectively:

• Take the recommended dose of 800 mg (two 400 mg tablets) once daily, at least one hour before or two hours after meals.
• Swallow the tablets whole with water; do not crush or break them.
• Take Votrient without food, as food increases absorption and may lead to increased side effects.
• Take the medication at approximately the same time each day to maintain consistent blood levels. Do not exceed the prescribed dosage. 

Follow your oncologist's instructions precisely regarding dosage adjustments, which may be necessary based on your tolerance and response.

Side effects

While Votrient is effective for treating certain cancers, it may cause some side effects, including:

• Diarrhea
• Hypertension (high blood pressure)
• Hair color changes
• Nausea
• Fatigue
• Decreased appetite 

Most side effects are manageable and resolve shortly. However, contact your healthcare provider immediately if you experience severe or persistent symptoms.

Interactions

Understanding potential interactions is crucial when taking Votrient tablets to ensure safety and effectiveness.

Drug interactions

Certain medications can affect how Pazopanib works in your body:

• Strong CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin): These can increase Pazopanib concentration, potentially enhancing side effects.
• Strong CYP3A4 inducers (Rifampin, Phenytoin, Carbamazepine): These may decrease Pazopanib's effectiveness by reducing its concentration in the bloodstream.
• Medications affecting gastric pH (Proton Pump Inhibitors, H2-receptor antagonists): These can alter Pazopanib absorption.
• Warfarin and other anticoagulants: Pazopanib may interact with these medications, requiring close monitoring of blood clotting parameters.

Disease interactions

Certain health conditions require special consideration when using Votrient:

• Liver impairment: Pazopanib metabolism is primarily hepatic; dose adjustments are necessary for patients with moderate liver dysfunction, and the medication is not recommended for those with severe liver impairment.
• Cardiovascular conditions: Those with uncontrolled hypertension, recent cardiac events, or QT interval prolongation require careful monitoring when taking Pazopanib.
• Bleeding disorders: Pazopanib may increase bleeding risk; caution is advised for patients with bleeding predispositions or those taking anticoagulants.
• Thyroid dysfunction: Pazopanib can affect thyroid function, requiring regular monitoring of thyroid hormone levels.

Food interactions

Diet can significantly impact Pazopanib's effectiveness and safety:

• Grapefruit products: Avoid grapefruit juice and grapefruit as they can increase Pazopanib blood levels, potentially causing more side effects.
• High-fat meals: Taking Pazopanib with high-fat foods significantly increases absorption, which can increase the risk of adverse effects.
• Consistent timing: Take the medication consistently, either with food or without food, to maintain predictable absorption patterns.

Precautions

Before starting Votrient 400 mg, consider these necessary precautions:

• Regular liver function monitoring is essential, especially during the first months of treatment.
• Blood pressure should be well-controlled before starting therapy and monitored regularly throughout treatment.
• Inform your doctor about any history of heart problems, stroke, bleeding issues, or planned surgical procedures.
• Women should use effective contraception during treatment and for at least two weeks after the final dose.
• Votrient is not recommended during pregnancy as it may cause fetal harm; breastfeeding should be avoided during treatment.
• Regular monitoring of thyroid function, complete blood counts, and electrolytes is necessary throughout treatment.
• Immediately report unusual symptoms, such as severe abdominal pain, bloody stools, or yellowing of the skin, to your healthcare provider.

Why buy from us

When you buy Votrient 400 mg from GoodRxMedicine, you enjoy advantages such as:

• Competitive pricing on specialty oncology medications
• Authentic products
• Expert pharmaceutical guidance
• Convenient and discreet delivery 
• Dedicated customer support for cancer patients

FAQs

How long do I need to take Votrient 400 mg?

Votrient 400 mg is typically taken continuously until disease progression or unacceptable toxicity occurs. Most patients remain on therapy for several months to years, depending on their response and tolerance. Your oncologist will monitor your condition regularly and determine the appropriate duration of treatment.

Can Votrient 400 mg cure my cancer?

No, Votrient 400 mg is not considered a cure for advanced Renal Cell Carcinoma or soft tissue sarcoma. Instead, it helps control cancer growth, potentially shrinking tumors and extending the time before the disease progresses. It's a necessary treatment that may significantly improve quality of life and survival time.

What should I do if I miss a dose of Votrient?

If you miss a dose of Votrient 400 mg and it's less than 12 hours until your next dose, skip the missed dose. Take the missed dose if it's more than 12 hours until your next dose. Never take a double dose to make up for a forgotten one, as this could increase side effects.

How quickly does Votrient 400 mg work?

Pazopanib begins working in your system within hours of taking it, but visible effects on tumors typically take several weeks to manifest. Your doctor will schedule regular imaging studies, usually every 8-12 weeks, to evaluate the medication's effectiveness in controlling your cancer.

Will my hair fall out while taking Votrient?

Unlike traditional chemotherapy, Votrient 400 mg typically doesn't cause complete hair loss. However, it commonly causes hair color changes, making hair appear lighter or grayer. Some patients may experience hair thinning. These changes are usually reversible after stopping treatment.

How should I store Votrient 400 mg?

Store Votrient 400 mg tablets at room temperature (68°F to 77°F or 20°C to 25°C), away from excess heat and moisture. Keep the medicine in its original container, tightly closed, and out of reach of children. Do not store in the bathroom or kitchen where humidity levels may increase.

Can I take over-the-counter medications with Votrient?

Always consult your oncologist before taking any over-the-counter medications, supplements, or herbal products with Votrient 400 mg. Common medications like NSAIDs (ibuprofen, aspirin) may increase bleeding risk, and certain supplements can interfere with Pazopanib's effectiveness or safety profile.