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Topinate 0.05% Cream 30 gm

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About Topinate

Topinate cream is a steroidal anti-inflammatory treatment for a variety of skin problems. 

It treats immune-responsive skin illnesses such as Psoriasis (itchy, red, and scaly), Eczema (red, cracked, and patchy), and Allergies. 

It reduces the skin's swelling, redness, and itchiness and prevents further irritation.

This prescription-only medication is only available with a doctor's prescription.

Systopic Laboratories Pvt. Ltd., a leading pharmaceutical company, manufactures Topinate cream 30gm

Topinate cream uses

It is prescribed for various skin conditions:


Dermatitis is an umbrella word for common skin irritation. It has numerous origins and symptoms, typically itchy, dry skin or a rash. 


Eczema is characterized by red, itchy, patchy, and cracked skin. Topinate, 0.05% Cream, is utilized to treat this condition.


Psoriasis is an immune-mediated disease that causes inflammation in the body.
It is characterized by inflammation caused by immune system dysfunction. There may be signs of inflammation, like raised plaques and scales on the skin.

Lichen Planus

Lichen Planus is a disease that causes irritation and swelling of the skin, hair, nails, and mucous membranes. Lichen Planus typically appears on the skin as flat, purple, itchy pimples that form over weeks.

How does Topinate work 

Due to allergic responses or irritation, the skin becomes inflamed, producing numerous chemicals.
Consequently, the blood vessels widen, and the irritated skin turns red, swollen, itchy, and unpleasant. 

Topinate skin cream contains Clobetasol Propionate, which is a Corticosteroid (Steroid) which means it helps to reduce inflammation in the skin.

It works within the skin cells to prevent the release of inflammatory chemicals, lowering inflammation, redness, and itching.

How to use Topinate

Use this medication only for the prescribed condition:

  • Only apply this medication to the skin. Do not apply it to the face or underarms unless your doctor instructs you to
  • Hands should be washed and dried before use. Wash and dry the affected region
  • Apply a thin layer of medication to the affected area and rub it in gently, typically twice daily or as your doctor directs
  •  Do not bandage or cover unless your doctor instructs you to do so
  • Avoid getting this medication in the eyes when applying it near the eyes, as this may worsen or cause Glaucoma
  • Avoid getting this drug in your nose or mouth. If the medication enters these areas, thoroughly rinse with water
  • Use it till the time your doctor has advised, otherwise do not use it for more than two consecutive weeks 

Side effects of Topinate

These mentioned side effects are rare. However, if it causes you any concerns, consult your doctor right away.

  • Burning sensation at the application site
  • Dry skin
  • Redness of skin
  • Itching of skin

Follow your doctor's instructions to prevent these effects


Drug Interaction

Please inform your doctor about other Corticosteroid medications and topical medications you are taking 

  • Oral Corticosteroids (such as Prednisone) 
  • Medicines that lower the immune system (such as Cyclosporine)
  • Insulin
  • Pioglitazone
  • Acarbose
  • Ritonavir (HIV medicine)

Disease Interaction

Topinate might interact with certain diseases:


Corticosteroids are reported to cause Adrenal Gland suppression. The risk for this condition is higher when this medicine is used for an extended period.


Since this medication reduces the hyperactivity of the immune system, if you take it during an active infection, your immune system may be unable to fight other infections.

Ocular Toxicities

Treatment with Topinate cream increases intraocular pressure and causes Glaucoma or Cataracts. Therefore, it is preferable to inform your doctor if you have any vision problems.


Corticosteroids can increase blood glucose by antagonizing the action and decreasing insulin secretion.

This inhibits peripheral glucose uptake and promotes Gluconeogenesis.

Precautions before using Topinate

  • Avoid taking this medication if you are allergic (hypersensitive) to this medication or any of its ingredients
  • Before using this drug, inform your doctor of your medical history, highlighting: poor blood circulation, immune system issues, and specific skin disorders (Rosacea, Perioral Dermatitis)
  • Prolonged doses of Topinate skin cream inhibit the growth of children. These growth disorders may be associated with metabolism or physical development
  • Topinate cream 30gm is only recommended for topical application. Avoid contact with the eyes, mouth, and broken or wounded skin
  • Covering the treated region with airtight coverings, such as bandages, without a doctor's approval may raise the chance of adverse effects
  • If applied concurrently, Topinate cream may interact with other topical medications. Do not apply any other topical medications on top of this cream


  • The recommended storage conditions for Topinate skin cream include room temperature, protection from direct sunshine, and dryness
  • Keep it away from children and pets.

Frequently Asked Questions 

Can I use Topinate cream on the face?

Do not apply Clobetasol-containing cream on the face, groin, underarms, or skin thinning unless your doctor instructs you.

Who should not use Clobetasol?

Topinate contains Clobestrol, which is a Corticosteroid that has very high strength. Due to the increased likelihood of adverse effects, it is not suggested that minors under 18 use it.

What is the Topinate containing Clobetasol used for?

Clobetasol Propionate treats inflammation, itching, and irritation on the skin. It can assist with skin conditions such as Eczema, Contact Dermatitis, and Psoriasis.

Is Clobetasol good for pimples?

Clobetasol is not to treat Acne, Fungal, or Viral skin infections.

How long does it take Clobetasol to work?

Clobetasol takes around 2-4 weeks to show its effect, like clearing Psoriasis patches.

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