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Drugs That Cause Erectile Dysfunction

Julian Carter


drugs that cause erectile dysfunction

Erectile Dysfunction (ED) is a Sexual Dysfunction. It makes it difficult for a man to get and keep a desired erection for sexual intercourse.

Innumerable risk factors can lead to impotence or ED in men. The risk factors for ED include stress, Obesity, Hypertension, Cardiovascular conditions, Diabetes, etc.

Some medicines might cause temporary or permanent ED as a side effect.

The worst offenders in ED include anti-depressants, beta-blockers, diuretics, and 5-alpha-reductase Inhibitors (5-ARIs).

Consult your doctor if you believe your medicine is the source of your erection issues. Stopping the medicine or reducing your dosage can help put ED at bay.

Thus, let’s dive in deep to understand which medicine is responsible for ED.

Read Does Lisinopril Cause ED and know if male impotence can be caused by Lisinopril or not?

Medications that cause Erectile Dysfunction

Medications that cause Erectile DysfunctionSource: Getty-images
Medications that cause Erectile Dysfunction

Some drugs are responsible for causing ED in men, with standard or rare side effects.

Hypertension drugs that cause Erectile Dysfunction

Although all blood pressure drugs can cause ED. Thiazide Diuretics and Beta Blockers are most likely to do so. 

Some may reduce the amount of blood that reaches your penis. Further, it can make erections challenging.

Diuretics and blood pressure medicines that frequently cause ED include

Anti-anxiety or Anti-depressant pills

Sexual Dysfunction is one of the most common side effects of anti-depressant pills.

You might also want to know if you can take antidepressants with ED pills. Read Can you take Viagra with antidepressants?

Men might notice a decline in sex drive as a result. Moreover, they struggle to achieve and maintain an erection.

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Certain anti-depressants not only decrease sexual desire but can also cause orgasmic Dysfunction.

These anti-depressants also impact erectile function. Lexapro, for example, may cause ejaculation to be delayed.

According to the study, 30 to 60% of SSRI users report having a sexual dysfunction.

Several anti-depressants, including the following medications, are known to affect sexual behavior.

  • Sertraline Citalopram
  • Fluoxetine
  • Paroxetine
  • Duloxetine
  • Escitalopram

You may experience fewer erections or diminished performance. 

These can be an outcome if you are on these pills.

Some anti-anxiety drugs that don’t cause Erectile Dysfunction are:

  • Bupropion (Wellbutrin XL, Wellbutrin SR)
  • Mirtazapine (Remeron)
  • Vilazodone (Viibryd)
  • Vortioxetine (Trintellix)


To treat seasonal allergies and other diseases, many people use Antihistamines. 

These typical OTC medications stop the body’s production of histamine. It further improves allergic reactions. 

Yet, they are also known to affect normal erections.

Other typical Antihistamines that might result in ED include:

  • Benadryl
  • Diphenhydramine
  • Dimenhydrinate
  • Hydroxyzine

Opioid painkillers

Opioids and ED go hand in hand as well. Long-term opiate use can result in decreased testosterone levels and ED.

If you face a tough time with ED, you can always take Viagra. Yet, Viagra is a prescription-based medicine, and it should be taken only when the doctor recommends it.

These are some instances of prescribed Opioid drugs:

  • Hydrocodone
  • Oxycodone
  • Morphine

Medicine for indigestion

Medicine for indigestionSource: Getty-images
Medicine for indigestion

Some acid reflux drugs, such as H2 blockers, influence histamine, resulting in ED. 

They consist of the following:

  • Cimetidine
  • Nizatidine

Summing up

Now that you are aware of drugs that cause Erectile Dysfunction. You should know that some of the common drugs and medicines used by people are Hypertension pills, Opioid painkillers, Antihistamines, etc

However, these drugs might have certain risk factors as well. These risk factors include conditions like Erectile Dysfunction in men. The list of drugs that cause Erectile Dysfunction includes Antidepressants, Antihistamines, etc.

Although, ED can easily be treated with doctor’s recommended medicines like Viagra.

5-alpha-reductase inhibitors: It is a class of medications used to treat Male Pattern Hair Loss and Benign Prostatic Hyperplasia, an Enlarged Prostate gland.

Frequently Asked Questions

What blood pressure drugs cause Erectile Dysfunction?

Blood pressure pills belonging to Thiazide Diuretics, Beta-blockers, etc., may cause ED.

What illegal drugs cause Erectile Dysfunction?

Nicotine, Amphetamines, Barbiturates, etc., can cause Erectile Dysfunction in men.

Why do drugs cause Erectile Dysfunction?

Drugs do have some risk factors. These risk factors might include several conditions, including Erectile Dysfunction (ED). Some medications might consist of ED as a side effect. These include Hypertension drugs, Anti-depressant pills, Opioid painkillers, etc.

What are the most common medications that cause Erectile Dysfunction?

The most common drugs which cause ED include Hypertension, Anti-depressant pills, etc.

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