Testosterone gel primarily treats men with Low Testosterone levels due to medical conditions. Many people use it to feel stronger, improve energy, or treat low hormone levels.
The gel helps improve Low Testosterone symptoms such as low energy, reduced muscle mass, decreased libido, and mood changes. It is easy to apply and works through the skin.
However, like all medicines, it may cause side effects. For example, if you’re going through In Vitro Fertilization (IVF), Testosterone gel side effects could affect your treatment. But most of these effects are mild and go away with time.
This article explains the most common, rare, and surprising Testosterone gel side effects. Stay till the end to learn how to use it safely and what to watch for during treatment.
Common side effects of Testosterone gel
Many people tolerate Testosterone gel well, but some experience mild side effects. These side effects often improve as their bodies adjust to the medication.
Common side effects include:
- Skin irritation where the gel is applied, such as redness, itching, or rash
- Acne or oily skin
- Changes in mood, including irritability or mild Depression
- Headaches or dizziness
- Breast tenderness or swelling (Gynecomastia)
- Changes in sexual desire or function
- Increased hair growth or hair loss
These side effects are typical for both men and women.
Serious Testosterone gel side effects to watch for
While uncommon, some Testosterone gel side effects require immediate medical attention. These include:
- Signs of heart matters include chest pain, shortness of breath, or sudden weakness.
- Swelling or pain in your legs, which could mean blood clots.
- Severe allergic reactions include swelling of the face, lips, tongue, or difficulty breathing.
- Yellowing of the skin or eyes, nausea, or dark urine indicates liver problems.
- Changes in urination or signs of prostate enlargement.
- Mood changes such as severe Depression or aggressive behavior.
If you experience any of these severe side effects, stop using Testosterone gel and seek medical help right away.
Side effects of using Testosterone gel in males vs females
Men and women may experience different side effects due to hormonal differences.
Men using Testosterone gel may notice side effects specifically linked to their gender. Some common side effects of Testosterone gel in men include:
- High red blood cell count, which can raise clotting risk.
- Possible worsening of prostate symptoms.
- Fluid retention leads to swelling.
- Changes in mood or sleep apnea.
Women taking Testosterone gel may face unique side effects. Side effects of Testosterone gel in women can include:
- Voice deepening
- Increased body hair
- Menstrual changes
Women who are pregnant or may become pregnant should avoid contact with Testosterone gel due to the risk of birth defects.
Side effects of stopping Testosterone gel use
Stopping Testosterone gel suddenly can cause withdrawal symptoms or a return of Low Testosterone symptoms. You might notice:
- Fatigue or low energy
- Mood swings or Depression
- Decreased libido
- Muscle weakness
Always consult your healthcare provider before stopping Testosterone gel to plan a safe discontinuation.
Important precautions
Testosterone gel can transfer to others through skin contact. This is especially risky for women who are pregnant or trying to conceive and for children. To reduce this risk:
- Always apply the Testosterone gel to clean, dry skin.
- Cover the application skin area with clothing after the gel dries.
- Wash your hands thoroughly after applying.
- Don’t have skin contact with others at the application site.
- If accidental contact occurs, wash the affected skin immediately with soap and water.
These precautions related to how to apply Testosterone gel help protect your loved ones from unintended side effects of Testosterone medicine.

Conclusion
Testosterone gel can be a helpful treatment for Low Testosterone, but like any medicine, it may cause side effects. Testosterone gel side effects range from common mild reactions like skin irritation, acne, and mood changes to rare but serious issues such as heart problems and allergic reactions.
Most people only experience mild issues, and these common side effects of Testosterone gel often improve over time. Men and women may experience different side effects due to hormonal differences, with women facing unique risks like voice deepening and menstrual changes.
Stopping Testosterone gel suddenly can cause withdrawal symptoms, so always consult your healthcare provider before discontinuing. It’s crucial to follow precautions to prevent accidental transfer, especially to children and pregnant women.
Compared to injections, Testosterone gel offers convenience but may cause more skin-related side effects, while injections provide more stable hormone levels. Understanding these points helps you use Testosterone gel safely and effectively under medical guidance.
Frequently Asked Questions
Is Testosterone gel harmful?
No, Testosterone gel is not harmful when used correctly. It helps many people feel stronger and more energetic. However, like any medicine, it can cause side effects. You should follow your doctor’s instructions and watch for any changes in your body to stay safe.
How do you feel after using Testosterone gel?
After using Testosterone gel, you may feel more energetic and stronger. Many people notice a better mood and more interest in activities. Some feel more confident and active. These changes usually start within a few weeks, but everyone is different, so your experience may vary.
Does Testosterone gel cause liver damage?
No, Testosterone gel usually does not cause liver damage. It is absorbed through the skin, affecting the liver less than some other forms of Testosterone. However, tell your doctor immediately if you notice yellow skin, dark urine, or stomach pain.
Where to apply Testosterone gel in males?
You should apply Testosterone gel to clean, dry skin on your shoulders, upper arms, or stomach. Avoid using it to your genitals or broken skin. Always follow your doctor’s instructions and wash your hands after applying to keep others safe from contact.
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