Syndopa CR 50 + 200 mg

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What is Syndopa CR

Syndopa CR tablet combines two medicines, Levodopa (200 mg) and Carbidopa(50mg).

It is used to treat Parkinson's disease (a disorder that affects the nervous system).

One of the most effective medicine for treating the symptoms of Parkinson's disease, including tremors, muscle stiffness, trouble moving, impaired balance, and coordination.

This prescription-based medicine is FDA-approved and is not available over the counter. 

Sun Pharma Laboratories is a renowned pharmaceutical company that manufactures Syndopa CR 250. 

Uses of Syndopa CR

Syndopa CR 250 mg effectively treats the symptoms of Parkinson's disease.

Parkinson's disease

Parkinson's disease is a progressive condition affecting the nervous system and nerve-controlled body portions.

It leads to the gradual loss of muscle control and causes uncontrollable movements. 

The main symptoms of Parkinson's disease are tremors, slowing of movements, slurred speech, rigid muscles, loss of automatic movements, impaired posture, and loss of coordination.

Symptoms of Parkinson's disease are mild in the starting, but they progressively worsen over time.

How does Syndopa CR work 

Parkinson's disease affects the nerve cells (neurons) in the Substantia Nigra area of the brain.

Normally, these cells produce Dopamine, a chemical (neurotransmitter) that transmits signals between different regions in the brain. 

When functioning normally, it coordinates smooth and balanced muscle movement. 

Parkinson's disease causes the death of nerve cells that produce Dopamine and affects the body's movement.

Syndopa CR 250 mg combines two medicines, Levodopa (200 mg) and Carbidopa(50mg).

Levodopa converts to Dopamine in the brain, which helps to regulate movement. 

Carbidopa inhibits Levodopa's breakdown in the bloodstream, allowing more Levodopa to enter the brain. It can also reduce specific side effects of Levodopa, such as Nausea and Vomiting.

How to take Syndopa CR

  • Take this medication orally as your doctor prescribes, usually three to four times daily
  • During treatment, it is advisable to avoid a high-protein diet (which limits the amount of Levodopa your body takes in) unless otherwise directed by your doctor
  • Your doctor may urge you to start this medicine at a low dose and gradually raise it to limit your chance of side effects
  • Utilize this medication routinely to obtain the maximum benefit
  • Swallow the whole medicine. Avoid breaking, chewing, or grinding

Syndopa CR side effects 

Syndopa CR 250 is a safe medicine if used as advised by a physician.

However, some patients may experience the following side effects:

Visit your doctor immediately if any of the side effects cause you concern.


Interactions can occur when the constituents of a medicine interact with another medicine, disease, or food.

Drug Interaction

Syndopa CR 250 mg is known to interact with several medications occasionally, including: 

  • Antipsychotic medicines (Thioridazine)
  • Medicines to treat high blood pressure (Methyldopa)
  • MAO inhibitors (Moclobemide, Safinamide)
  • Furosemide
  • Pyridoxine
  • Quetiapine
  • Rosuvastatin
  • Rasagiline

Disease Interaction

It may interact with conditions such as:

  • Melanoma
  • Reactive airway disease
  • Cardiac disease
  • Hypotension
  • Neuroleptic malignant syndrome
  • Psychoses/Depression
  • Glaucoma
  • Liver/Renal


Adhere to some cautions while taking Syndopa CR.

  • Inform your doctor if you're allergic to Carbidopa or Levodopa
  • Due to the increased risk of drowsiness, the Syndopa CR tablet should be administered with care. It can also cause you to fall asleep during daily tasks. Therefore, avoid engaging in activities that require alertness, such as driving or operating heavy machinery
  • If you have liver problems and your liver isn't functioning properly, this medicine may accumulate, causing toxicity
  • During pregnancy, only use it if needed. Discuss risks and benefits with your doctor
  • Small levels of Levodopa enter breast milk and may alter milk production. Before breastfeeding, talk to your doctor


  • This medicine must be kept in a dry, dark location away from direct sunlight
  • Keep out of children's reach

Frequently Asked Questions 

What are the side effects of Syndopa?

Side effects of Syndopa include Dizziness, stomach pain, loss of appetite, dry mouth, fatigue, Hallucinations, Headache, abnormal dreams, etc.

How long does Syndopa take to work?

Within 20 to 50 minutes, the short-acting (immediate-release) formulation of Carbidopa and Levodopa starts showing its effect.

Can Syndopa be stopped?

Do not discontinue Levodopa and Carbidopa without first consulting your physician. 
If you abruptly stop taking them, you may get a severe condition characterized by fever, muscle rigidity, odd body movements, and confusion. 
Your doctor will progressively reduce your dosage.

What to do if you miss a dose of Syndopa CR?

Take Syndopa immediately when you recall. If the time of your next dose is approaching, skip the missed dose. 

What is the best time of day to take Levodopa and Carbidopa?

Taking your first daily dose 1 to 2 hours before your morning meal may be optimal. Taking Carbidopa with Levodopa immediately after a meal high in fat and calories is not advisable. It can prolong the time it takes for the body to absorb and feel the effects of the medicine.

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