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Neksium 40 Mg

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Dr. Akanksha Kaushal
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Written by
Julian Carter
julian-carter Julian Carter

Julian, an MBA in Pharmaceutical Management, brings a dynamic blend of expertise and impact with his contributions at Goodrxmedicine. His dedication and innovative spirit continue to shape a brighter future in pharmaceutical management.

About Neksium 40 mg

The Neksium 40mg tablet is a medication that can help lower the acid production in your stomach.

This medication contains Esomeprazole as an active ingredient.

It treats and prevents, Ulcers, Acid reflux and other issues affecting the digestive tract.

Pfizer Limited specializes in manufacturing 40 mg Neksium.


Neksium 40 treats the following conditions:

  • Gastroesophageal Reflux Disease (GERD): It is a chronic condition in which stomach acid or bile enters the esophagus and irritates its lining
  • Erosive Esophagitis: a severe type of GERD in which the esophagus is injured
  • Zollinger-Ellison Syndrome: Small intestine tumors result in excess acid production in this syndrome
  • Stomach Ulcers: also referred to as Gastric Ulcers, are painful sores in the stomach lining


Esomeprazole is classified as a Proton Pump Inhibitor (PPI).

Proton Pump is the ultimate channel for the secretion of Hydrochloric Acid by the parietal cells in the stomach.

This blockage results in a significant reduction in the amount of Hydrochloric Acid secreted into the stomach and caused a change in the pH of the gastric fluid.

It is advisable to take this medication first thing in the morning.

How to use it Neksium 40

It is essential to follow the instructions provided by your healthcare provider when taking the medication.

Take each dosage with a whole 8-ounce glass of water

Take the pill as it is, without crushing, chewing, or breaking

If you cannot take a whole capsule, you can open it and sprinkle the contents into pudding. Immediately ingest the mixture without chewing. Avoid storing it for long

An alternative to Neksium 40 mg can be Aciloc 150 mg, containing Ranitidine as an active ingredient, which is also used in treating excessive stomach acid.

Side effects

This medication can induce some mild to moderate side effects, such as:

  • Headache
  • Nausea
  • Diarrhea
  • Gas
  • Constipation
  • Dry mouth
  • Drowsiness
  • Blisters, peeling or bleeding skin
  • Irregular, fast, or pounding heartbeat


Interactions may diminish the effectiveness of your drugs or increase the risk of adverse effects. Discuss possible drug, illness, and food interactions with your doctor.

Drug interactions

Avoid the following medication while consuming Neksium 40 mg:

  • Antifungal medication like Ketoconazole, Voriconazole
  • HIV/AIDS medication Atazanavir, Nelfinavir, Saquinavir
  • Cilostazol
  • Digoxin
  • Clopidogrel
  • Diazepam
  • Iron-containing medicines
  • Methotrexate
  • Rifampin
  • Herbal medications
  • Warfarin

Disease interactions

You should avoid Neksium tablets if you have the following:

  • Liver disease
  • Low levels of magnesium in your blood
  • Lupus
  • Osteoporosis or low bone mineral density (Osteopenia)


Keep the following in mind before and after consuming the medication:

  • Consult a physician before using Neksium 40mg tablet during pregnancy or nursing
  • Take this medication for the amount and duration prescribed
  • Avoid excessively carbonated beverages, citrus juices, fried foods, and caffeinated beverages such as tea and coffee
  • Notify your primary care physician if you have a fever, Diarrhea, or stomach pain for an extended period
  • Long-term usage of Neksium 40 mg tablet can result in brittle bones and mineral deficiencies, such as magnesium insufficiency. Therefore, consume this medicine till the time your doctor prescribes it

Frequently Asked Questions

What is Neksium 40 mg used for?

Neksium 40 mg is specially formulated to treat Gastroesophageal Reflux Disease (GERD), Erosive Esophagitis, Zollinger-Ellison Syndrome, and Stomach Ulcers.

How do Neksium tablets work?

Esomeprazole, the active ingredient in Neksium 40 mg, belongs to Proton Pump Inhibitors (PPI) group. It is responsible for decreasing the amount of acid produced by the stomach, which, in turn, alleviates acid-related symptoms such as indigestion and heartburn.

When should I take Neksium 40 mg?

The Neksium 40 mg tablet should be taken 60 minutes before to meal. Take this medication daily at the same time to maintain a steady blood level of Neksium tablet. Do not discontinue this medication without discussing it with your physician since your symptoms may return.

Can I drink alcohol with Neksium 40?

While alcohol does not appear to interact with 40 mg Neksium, it can increase stomach acidity and exacerbate digestive problems. Because of this, you shouldn't drink alcohol.

Can Neksium 40mg tablets be used for bloating?

No, Neksium 40 mg is not a medication used to relieve bloating. It is prescribed to treat symptoms of excessive acid production in the stomach, such as heartburn and acid indigestion.

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