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What is Tadalafil Used For? Approved and Off-label Uses

Julian Carter
Published

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What is Tadalafil Used For

Tadalfil is not just used for Erectile Dysfunction (ED) treatment. It treats several different health conditions, some approved uses, while others are experimental.

Its effects last up to 36 hours, making it suitable for prolonged benefits or relief. Due to its established safety profile and duration of action, Tadalafil features in studies evolving newer treatments for managing health conditions like pelvic or circulatory issues.

So, what is Tadalafil used for today? Let’s dive into the established, Food and Drug Administration-backed (FDA-backed) roles and some newer, innovative applications that medical science is exploring to make smart and informed decisions. 

Tadalafil uses: Proven and potential

Tadalafil is a Phosphodiesterase 5 (PDE5) inhibitor that mainly works by relaxing the smooth muscles. Under a doctor’s care, it can address several health conditions.

Below are the recognized uses and experimental or off-label uses listed separately, so you can understand what Tadalafil is used for and how to use it.

FDA-approved uses of Tadalafil

These uses, supported by research and approved by regulatory agencies, are:

  • Erectile Dysfunction (ED): Tadalafil enables men with ED to achieve and maintain erections firm enough for sexual activity, providing a much longer therapeutic window than most similar medications. It works by promoting more blood flow to the genital area.
  • Benign Prostatic Hyperplasia (BPH): For symptoms such as frequent or urgent urination due to an Enlarged Prostate, Tadalafil helps relax smooth muscle in the lower urinary tract, often chosen to treat BPH symptoms with or without ED.
  • Pulmonary Arterial Hypertension (PAH): At higher doses, Tadalafil is prescribed to lower blood pressure inside the lungs, making it easier to exercise and preventing disease progression in adults diagnosed with PAH.
Did you know?
About 2.4 million Tadalafil prescriptions were written in the US in 2023.

Off-label uses for Tadalafil

While not approved by the Food and Drug Administration (FDA) for these indications, doctors sometimes prescribe Tadalafil for other purposes, based on emerging evidence or specialist judgment:

  • Raynaud’s phenomenon (numb or cold toes and fingers): Tadalafil is explored for its ability to manage this phenomenon and improve blood flow in small vessels, reducing episodes of cold, bluish fingers or toes.
  • Post-surgical recovery: After certain prostate or pelvic surgeries, Tadalafil may be recommended to support the recovery of urinary or sexual function.
  • Female sexual dysfunction: Tadalafil may be prescribed to females having genital arousal disorder and Selective Serotonin Reuptake Inhibitor (SSRI) induced sexual dysfunction. It may also be suggested to generally enhance the sexual experience under the guidance of a doctor.
  • Female pelvic conditions: Ongoing studies are evaluating its potential in select women for bladder or vascular disorders, but routine use is not established.
  • Other circulatory issues: In rare, off-label cases, Tadalafil has been explored for conditions like Cerebral Small Vessel Disease (CSVD) and refractory Angina, particularly when conventional therapies are ineffective. However, caution is needed when taking medicines like Nitrates.
Warning:
Some counterfeit Tadalafil products sold online may contain only traces of the actual medicine or be tainted with undisclosed substances. Fake medicines risk ineffective treatment and serious health harm. Always obtain Tadalafil medicines from a licensed pharmacy with a valid prescription.

How to use Tadalafil?

Tadalafil dosage and administration vary depending on what Tadalafil is used for:

  • For ED: It can be taken once as-needed, 30-60 minutes before sexual activity, or as a low daily dose for continuous effect, as advised by your doctor.
  • For BPH or PAH: Usually prescribed as a fixed daily dose at the same time each day. Adherence ensures steady benefits.
  • For other purposes: Depending on the condition and severity, the dosage and frequency are adjusted.
  • Administration: Swallow the tablet or jelly whole, with or without food, and never take more than recommended. For strips, let them dissolve completely in the mouth. Before starting, share your complete medical and medication history with your provider.

Conclusion

Tadalafil is used for managing multiple health conditions. These uses span FDA-approved purposes such as ED, BPH, and PAH, as well as selective off-label opportunities like Raynaud’s phenomenon and female sexual dysfunction. 

Based on the condition and prescription, it can be taken once daily or as needed. Despite its reliable safety profile, you should never use it without medical consultation or exceed the prescribed dosage.

Understanding what is Tadalafil used for can help guide meaningful conversations with your healthcare provider and promote safe, effective outcomes.

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Frequently Asked Questions

Can Tadalafil help manage altitude sickness or other high-altitude conditions?

Yes, emerging research suggests that Tadalafil might improve pulmonary function and exercise tolerance in high-altitude environments by relaxing blood vessels in the lungs. It is used off-label to prevent High-Altitude Pulmonary Edema (HAPE) in altitudes above  2500-3000 meters. However, it is only used under strict medical supervision.

Is Tadalafil used to enhance athletic or bodybuilding performance?

No, despite rumors, Tadalafil is not designed or recommended for athletic performance. While its vessel-dilating effects have theoretical appeal, there’s no proven benefit for sports or muscle gain, and off-label use risks unexpected side effects and complications.

Can Tadalafil affect mood or mental well-being?

Yes, a small number of users have reported changes in mood or mild Anxiety with Tadalafil, possibly due to blood flow changes or indirect effects on confidence and quality of life. Consult your provider for guidance and support if you have persistent mood changes.

Are there any specific storage instructions for Tadalafil tablets or liquids?

Keep Tadalafil tablets in their original container, away from moisture and heat, and out of reach of children. Liquid Tadalafil, if prescribed, should be kept refrigerated or as directed by your dispensing pharmacy for best stability and safety.

Can Tadalafil be used in combination with other medications for sexual health?

No, Tadalafil should not be routinely combined with other PDE5 inhibitors or similar medicines. In certain complex cases, specialists may layer treatments for unique medical reasons, but this approach always requires close medical supervision to avoid adverse interactions.

Citations:
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