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Januvia 100 mg

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Medically Reviewed by
Dr. Akanksha Kaushal
akanksha-kaushal Dr. Akanksha, Pharm-D

Dr. Akansha is a licensed Clinical Pharmacologist with extensive expertise in pharmacovigilance, prescription analysis, drug information, and safety. She's a dedicated educator and avid learner. Dr. Akansha also reviews medical content on GoodRx Medicine, ensuring accurate pharmaceutical information is accessible to all.

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Written by
Julian Carter
julian-carter Julian Carter

Julian, an MBA in Pharmaceutical Management, brings a dynamic blend of expertise and impact with his contributions at Goodrxmedicine. His dedication and innovative spirit continue to shape a brighter future in pharmaceutical management.

About brand name of the drug

Januvia 100 mg is a brand of medicine manufactured by one of the largest pharmaceutical companies in the world, MSD. MSD is an America based multinational pharmaceutical company with its subsidiaries all over the world. Januvia 100 mg is an allopathic medicine used for the treatment of people suffering from Type 2 diabetes. Type 2 diabetes is the condition when there is high sugar level in the blood, resistance against insulin is developed and relatively low levels of insulin is generated in the body. Januvia 100 mg is a known drug for the treatment of all these symptoms along with a strict diet and exercise regimen.

About the drug 

Januvia 100 mg is composed of Sitagliptin as the Active Pharmaceutical Ingredient. It is generally used alone or in combination with other medicines accompanied with a strict diet and physical exercise regimen for the treatment of type 2 diabetes. Januvia is available in the form of oral tablets and injection. Oral tablets of Januvia are available in the strength of 25 mg, 50 mg and 100 mg. Januvia 100 mg is easily available in the medical stores as well as various online pharmacy platforms. The brands equivalent to this available in the US markets are :

  • Januvia
  • Istavel
  • Zita

About salt of the drug

Sitagliptin is a salt which shows the therapeutic effect to treat type 2 diabetes. It functions by inhibiting the enzyme which is responsible for destroying the Glucose affecting hormones of the blood. Thus the increase concentration of these hormones are increased by Januvia and the action of the hormones is prolonged resulting in stable blood glucose levels. Januvia 100 mg tablet is used for the treatment of following medical conditions :

  •  Type 2 Diabetes Mellitus

Medical Uses of the drug

Januvia 100 mg I used to treat the medical condition of :

  • Type 2 Diabetes Mellitus which is associated with symptoms like high blood glucose levels, insulin resistance and low production of insulin 

Working of a drug 

Januvia 100 mg is used for the treatment of type 2 Diabetes Mellitus either in monotherapy or combination therapy with other medicine. It acts by reducing the blood glucose levels by inhibiting an enzyme. The enzyme inhibits glucose regulating hormones thus causing imbalance in Glucose levels in the blood. Januvia 100 mg inhibits the enzyme and helps to restore the normal blood glucose levels. It also increases the level of insulin formation from the pancreas and regulates the glucose metabolism for both fasting and postmeal conditions.

Side effects 

 The treatment with Januvia 100 mg are related with the manifestation of few side effects. These side effects can differ from person to person depending on the severity of the condition and several other factors. The common side effects observed are :

  • Headache
  • Infection of upper respiratory tract
  • Inflammation of the throat and nasal passages
  • Anxiety
  • Chills
  • Vision is blurred
  • Sense of confusion
  • Nausea
  • Cough
  • Fever
  • Sore throat

These are side effects are common and for a shorter duration of time while undergoing treatment with Januvia 100 mg . But if any of these symptoms of side effects prevails for a longer period of time, it is advisable to inform a physician as soon as possible.

How to use 

  • Januvia 100 mg should be taken only under the consultation and supervision of the physician
  • The general dose of Januvia 100 mg which is recommended by the physician is one tablet regularly
  • The tablet can be taken either with food or without food depending on the conditions of your blood sugar level and advise of your doctor
  • The tablet is taken with a glass of water and swallowed whole without being crushed or chewed
  • A strict diet and regular exercise is necessary to follow to maintain the blood glucose levels while taking Januvia 100 mg
  • The tablet should be stored properly in a cool and dry place

Drugs that are known to interact with this medicine

Interaction between drugs are common when two or more drugs are taken simultaneously that react with each other. These drug interaction reactions can be harmful. Some drugs that are known to interact with Januvia 100 mg are :

  • Clozapine
  • Acetazolamide
  • Benazepril
  • Gatifloxacin
  • Bumetanide
  • Bexarotene
  • Propranolol
  • Pancreatin
  • Collagen peptide
  • Methylprednisolone
  • Deflazacort
  • Betamethasone
  • Paroxetine
  • Escitalopram oxalate

When to avoid taking the drug

Januvia 100 mg should not be prescribed to people who are suffering from the following conditions like :

  • Hypersensitivity to Sitagliptin
  • Diabetic ketoacidosis which is a serious diabetic condition in which excess amount of blood acids or ketones is produced
  • Type 1 diabetes mellitus
  • Disease of pancreas
  • Serious kidney problem
  • Gallstones
  • Alcohol addiction

Things to avoid when using the drug

consumption of certain food profi and beverages should be avoided while undergoing treatment with Januvia 100 mg like :

  • Alcohol : If alcohol is consumed while a person is taking Januvia 100 mg, severe adverse effects can be seen
  • Tobacco : The consumption of tobacco should also be avoided as it can result into side effects, worsening the condition

General Information and Precautions

  • Januvia 100 mg is a highly effective and potent drug and should be taken only after consultation with a physician 
  • Januvia 100 mg tablet is not prescribed for children or adults who are below the age of 18 years
  • Januvia 100 mg tablet is not known to cure type 2 diabetes but it is used to maintain and regulate the normal insulin and blood glucose levels
  • Januvia 100 mg should not be taken with any other random medication even if it is used to treat the same condition
  • The tablet should not be taken in more than the prescribed dose as it can result in severe side effects
  • Along with the medication of Januvia 100 mg, a strict diet and regular exercise is necessary to maintain the blood glucose levels


  • Pregnancy: Januvia 100 mg tablet is considered to be safe for use during pregnancy as it does not affect the fetus adversely
  • Lactation: The lactating mothers can safely use Januvia 100 mg tablets as the drug does not pass into the breast milk
  • Driving and handling machinery: If the blood sugar level is high or low the it is not usually safe to drive. Blurred vision and confusion can be experienced while treatment with Januvia and this driving or handling machines which needs alert senses should be avoided
  • Children or adolescents: Januvia 100 mg should not be used for children or adults who are below 18 years of age 
  • Kidney function: Januvia 100 mg tablet should be used with caution in patients suffering from any kind of liver diseases


  • Januvia 100 mg tablet should be kept out of sight of children and pets animals 
  • The blister pack of tablet should be kept away from direct heat and sunlight
  • It should be kept away from possible exposure to moisture
  • The tablet should not be thrown away , if expired it should be destroyed properly

General FAQs regarding the drug

How long does Januvia 100 mg takes to show its effect?

Ans. The immediate effect is generally seen after 2 weeks of taking Januvia 100 mg.

Is Januvia 100 mg known to cause gain in weight?

Ans. No, Januvia 100 mg is not known to increase the weight and also a strict diet is maintained along with it to control the body weight



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