Augmentin 500 Mg+125 Mg

Medically Reviewed by Dr. Akansha Kaushal

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Dr. Akansha Kaushal

Clinical Pharmacologist and Drug Safety Expert

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Written by Julian Carter

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Julian Carter

MBA in Pharmaceutical Management

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What is Augmentin 500 125 mg

Augmentin 500 125 mg is a broad-spectrum antibiotic to treat various bacterial infections. It contains two FDA-approved active ingredients: 500 mg of Amoxicillin and 125 mg of Clavulanic Acid, forming a potent antibacterial combination. As part of the penicillin class of antibiotics, it falls under the beta-lactam/beta-lactamase inhibitor category. 

Manufactured by GlaxoSmithKline Pharmaceuticals Ltd, this medication is mainly prescribed for moderate to severe infections, including those affecting the respiratory tract, skin, and urinary tract, and should be used under medical supervision.

Uses of Augmentin 500 125 mg

Augmentin 500 125 mg effectively helps the body fight infections caused by bacteria such as:

• Respiratory tract infections (e.g., Pneumonia, Bronchitis)

• Urinary tract infections (UTIs) 

• Skin and soft tissue infections (like cut infections)

It is also used for other conditions such as bone and joint infections, intra-abdominal infections, certain bite wounds, and dental (Odontogenic) infections. Additionally, it is prescribed for acute flare-ups of Chronic Obstructive Pulmonary Disease (COPD) and for treating mild to moderate intra-abdominal infections in select patients.

Working and benefits of Amoxicillin and Clavulanic Acid

Augmentin 500/125 mg tablet contains two active ingredients: Amoxicillin 500 mg and Clavulanic Acid 125 mg. Amoxicillin is a penicillin antibiotic that kills bacteria by stopping them from building protective cell walls. Some bacteria can resist it by making an enzyme called beta-lactamase. Clavulanic Acid blocks this enzyme, helping Amoxicillin work better against more bacteria. Together, they make Augmentin a strong and effective antibiotic.

Key benefits include:

• It offers wide-ranging protection against numerous types of bacteria.

• It helps treat infections that are resistant to other antibiotics.

• It starts acting within a few hours, quickly lowering bacterial levels and easing symptoms.

• It is highly effective and well-tolerated by the majority of patients.

• It is formulated to handle chronic or recurring infections with lasting results.

• Doctors and patients trust it for its consistent performance and effectiveness.

Dosage and how to take Augmentin 500 125 mg

Here are some general guidelines on how you can take the Augmentin 500 125 mg dosage safely: 

• Take the medication per the doctor's instructions.

• Swallow the whole tablet with water. Do not crush or chew it. 

• It should be taken with food.

• Take it at a fixed time daily for better results.

Always adhere to your doctor's instructions for practical usage and results while taking Augmentin. 

Side effects

Though well-tolerated, Augmentin may also cause some side effects:

• Nausea

• Vomiting

• Skin rash

• Itching

• Vaginal inflammation

• Diarrhea

These effects subside as the body adjusts to the medication and will not require medical attention. However, consult a doctor if the symptoms continue or worsen.

Interactions

Augmentin 500 125 mg oral tablet can interact with other medications you take, your health conditions, or specific foods or drinks.

Drug interactions

Medicines that can interact adversely with Augmentin are:

• Methotrexate

• Oral Anticoagulants (blood thinners)

• Probenecid

• Allopurinol

• Oral Contraceptive pills

It is not an exhaustive list. Please consult a healthcare provider to discuss any possible drug interactions with Augmentin.

Disease interactions

Patients with the following health conditions should be cautious while taking the medication.

• Liver Disease: Augmentin should be used cautiously, and regular liver function monitoring is advised in patients with pre-existing liver conditions.

• Kidney Impairment: Augmentin is not recommended for those with severe kidney disease unless taken under close medical supervision.

• Mononucleosis: The use of Augmentin in patients with Mononucleosis increases the risk of developing a severe skin rash. Caution is advised.

• Colitis: Augmentin may exacerbate or cause colitis (colon inflammation), especially if there is a history of gastrointestinal disease.

• Diabetes: Special caution is needed as Augmentin may affect glucose control or require monitoring in diabetic patients.

• Phenylketonuria (PKU): The liquid form of Augmentin contains phenylalanine, which is harmful to people with PKU. Tablets are preferred for these patients.

Always inform a healthcare provider about your medical history before starting Augmentin.

Food interactions

There are no known food interactions with Augmentin 500 125 mg. However, it is advised that you consult a healthcare professional before making any changes to your diet. 

Precautions

Users should follow these recommendations while taking or before taking the Augmentin 500-125 mg tablet:

• Do not take this medication if you are allergic to Penicillin or Cephalosporin antibiotics.

• While generally safe during breastfeeding, nursing mothers should consult their doctor before use.

• People with liver or kidney problems should take this medicine only under medical supervision to avoid potential risks.

• Pregnant women may use Augmentin 500 125 mg safely, but only under a doctor's guidance.

• Those with a history of colitis or digestive issues should use it carefully to prevent severe diarrhea.

• Inform your doctor about any other medications you are taking to avoid possible drug interactions.

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