{"id":445566,"date":"2026-06-20T09:40:30","date_gmt":"2026-06-20T09:40:30","guid":{"rendered":"https:\/\/www.goodrxmedicine.com\/blog\/?p=445566"},"modified":"2026-06-20T09:41:14","modified_gmt":"2026-06-20T09:41:14","slug":"is-pcos-an-autoimmune-disease","status":"publish","type":"post","link":"https:\/\/www.goodrxmedicine.com\/blog\/womens-health\/is-pcos-an-autoimmune-disease\/","title":{"rendered":"Is PCOS an Autoimmune Disease or a Metabolic Disorder?"},"content":{"rendered":"\n<p>Polycystic Ovary Syndrome (PCOS) is a hormonal and metabolic disorder in women. It can affect ovulation, blood sugar balance, skin, hair growth, mood, and quality of life. According to a 2024 meta-analysis, the condition affects 9.2% of women of reproductive age globally.<\/p>\n\n\n\n<p>On the other hand, autoimmunity is diagnosed when your immune system mistakenly attacks healthy cells, tissues, or organs. More than 100 such lifelong disorders have been identified, which are typically twice as common in women as in men.<\/p>\n\n\n\n<p>While both are distinct conditions, some PCOS symptoms, like low-grade inflammation and insulin resistance, can resemble those of autoimmune conditions. This is why the two conditions are often discussed together.  <\/p>\n\n\n\n<p>Read below to find out is PCOS an autoimmune disease, what is the connection between the two and when you should ask your doctor about further testing.  <\/p>\n\n\n\n<h2 id=\"is-pcos-considered-an-autoimmune-disease\" class=\"wp-block-heading\">Is PCOS considered an autoimmune disease?<\/h2>\n\n\n\n<p>No, PCOS is not an autoimmune disease; it is actually an endocrine and metabolic disorder. It develops when hormone signals, ovarian function, insulin response, and androgen (<a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/male-sex-hormone\/\" target=\"_blank\" rel=\"noopener\">male hormone<\/a>) levels fall out of balance. <\/p>\n\n\n\n<p>Its symptoms include irregular menstrual periods, Acne, unwanted facial hair and weight gain. Additionally, it can present with chronic low-grade inflammation. This means your body remains in a mild, ongoing inflammatory state rather than switching off after a normal immune response. It can overlap with how autoimmune conditions feel, especially when symptoms like fatigue, body aches, or brain fog appear. <\/p>\n\n\n<div id=\"goodr-779042397\"><!-- ===== GRX 4-Product Strip (responsive, WP-proof spacing) ===== -->\r\n<div class=\"grx-ss\" aria-label=\"Related products\">\r\n  <style>\r\n    .grx-ss{\r\n      --gap:12px;\r\n      --radius:12px; --border:#e6e6ef; --muted:#ADADAD; --title:#1f2937; --stars:#ffc107;\r\n      --price:#16a34a; --btn:#4107a1; --btn-h:#32067c; --btn-txt:#fff; --shadow:0 4px 14px rgba(9,30,66,.06);\r\n      --v-xs:4px; --v-sm:6px;\r\n      --img-h:180px;\r\n      --wp--style--block-gap:0 !important; \/* kill Gutenberg block gap inside *\/\r\n      display:block; width:100%; margin:0; padding:0; text-align:left;\r\n\r\n      \/* :white_check_mark: ensure spacing below the strip *\/\r\n      margin-bottom:20px !important;\r\n    }\r\n    .grx-ss *, .grx-ss *::before, .grx-ss *::after{box-sizing:border-box}\r\n\r\n    \/* Nuke theme margin on 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href=\"https:\/\/www.goodrxmedicine.com\/bigomet-500-mg-tablet-glucophage.html\" target=\"_blank\" rel=\"nofollow noopener\">Buy Now<\/a>\r\n  <\/article>\r\n<\/div>\r\n<\/div>\r\n\r\n<!-- ===== \/GRX 4-Product Strip ===== --><\/div>\n\n\n\n<h2 id=\"pcos-and-autoimmune-disease-connection\" class=\"wp-block-heading\">PCOS and autoimmune disease connection<\/h2>\n\n\n\n<p>Polycystic Ovary Syndrome and autoimmune diseases both can involve genetic factors, hormone changes and immune signaling. Thus, they are often discussed and studied together. So, while PCOS is not an autoimmune disease, some pathways can appear similar. This is what the studies say about these two conditions:<\/p>\n\n\n\n<h3 id=\"similar-antibodies-and-immune-markers\" class=\"wp-block-heading\">Similar antibodies and immune markers<\/h3>\n\n\n\n<p>Researchers have studied immune markers and autoantibodies (misguided antibodies that harm the body\u2019s own cells). Women with PCOS were found to have:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Anti-Thyroid Peroxidase (Anti-TPO) antibodies, which are linked to thyroid autoimmunity.<\/li>\n\n\n\n<li>Antinuclear Antibody (ANA), which is a blood marker for autoimmune conditions such as Lupus, Sj\u00f6gren\u2019s and Rheumatoid Arthritis.<\/li>\n<\/ul>\n\n\n\n<p>This suggests that further <a href=\"https:\/\/www.researchgate.net\/publication\/325017038_Evaluation_of_serum_anti-nuclear_antibody_among_women_with_PCOS_a_hospital_based_single_center_cross_sectional_study#:~:text=Higher%20prevalence%20of%20ANA%20positivity%20among%20women%20with%20PCOS%2C%20being%20a%20marker%20of%20autoimmunity%2C%20suggests%20a%20possible%20role%20of%20autoimmunity%20in%20causation%20of%20PCOS%20and%20needs%20further%20elucidation.\" target=\"_blank\" rel=\"noopener nofollow\">testing is needed<\/a> in women with PCOS if one or both of these markers come up positive. <\/p>\n\n\n\n<h3 id=\"insulin-resistance-overlap\" class=\"wp-block-heading\">Insulin resistance overlap<\/h3>\n\n\n\n<p>Due to hormonal imbalance, PCOS often involves insulin resistance. In this condition, the body requires more insulin to manage blood sugar. It can lead to sugar cravings, weight gain or <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/general-health\/diabetes-noncommunicable-deadly-diseases\/\" target=\"_blank\" rel=\"noopener\">Diabetes<\/a>. <\/p>\n\n\n\n<p>Likewise, Type B Insulin Resistance Syndrome (TBIRS) and Hirata&#8217;s Disease are autoimmune conditions that involve inflammation that affects metabolism. In TBIRS, antibodies attack insulin receptors, while in Hirata\u2019s antibodies attach to insulin itself, causing Hyperglycemia. They can also cause facial hair growth or irregular periods, similar to PCOS, which is why these are often confused.  <\/p>\n\n\n<div class=\"su-box su-box-style-soft\" id=\"\" style=\"border-color:#073d11;border-radius:10px;\"><div class=\"su-box-title\" style=\"background-color:#3A7044;color:#FFFFFF;border-top-left-radius:8px;border-top-right-radius:8px\">Fact<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:8px;border-bottom-right-radius:8px\"> Polycystic Ovary Syndrome has now been renamed as Polyendocrine Metabolic Ovarian Syndrome (PMOS). Since many women with PCOS do not have cysts, the new name better reflects its wider hormonal, metabolic, and psychological effects.  <\/div><\/div>\n\n\n\n<h2 id=\"risk-of-autoimmune-diseases-if-you-have-pcos\" class=\"wp-block-heading\">Risk of autoimmune diseases if you have PCOS<\/h2>\n\n\n\n<p>A hormonal-metabolic imbalance like PMOS, coupled with a genetic predisposition (autoimmunity cases in the family), is more likely to lead to one. Some autoimmune diseases linked to PCOS are listed below.<\/p>\n\n\n\n<h3 id=\"1-hashimotos-thyroiditis\" class=\"wp-block-heading\">1. Hashimoto\u2019s Thyroiditis<\/h3>\n\n\n\n<p>If you are experiencing persistent fatigue, hair thinning, cold sensitivity, or worsening menstrual irregularity, it could be due to an Autoimmune Thyroid Disease, especially Hashimoto\u2019s Thyroiditis. In this condition, the immune system produces antibodies that can affect thyroid function over time. Thus, you should discuss regular thyroid function tests with your doctor if you have PMOS. <\/p>\n\n\n\n<h3 id=\"2-lupus\" class=\"wp-block-heading\">2. Lupus<\/h3>\n\n\n\n<p>If you notice joint swelling, unexplained rashes, mouth ulcers, or repeated fevers alongside PCOS symptoms, it could be Systemic Lupus Erythematosus (SLE). Lupus is an autoimmune disease wherein the immune system affects the skin, joints, kidneys, blood, and other organs. Therefore, you should speak with your doctor about further evaluation if these symptoms recur.<\/p>\n\n\n\n<h3 id=\"3-type-1-diabetes\" class=\"wp-block-heading\">3. Type 1 Diabetes  <\/h3>\n\n\n\n<p>If you experience frequent urination, excessive thirst, unexplained weight loss or unusual fatigue, you should get tested for Type 1 Diabetes. It is an autoimmune disorder in which the immune system damages insulin-producing cells in the pancreas. <\/p>\n\n\n\n<p>A <a href=\"https:\/\/www.endocrinology.org\/endocrinologist\/158-winter-25\/hot-topics\/incidence-of-autoimmune-disease-before-and-after-pcos-diagnosis\/#:~:text=Glintborg%20et%20al,with%20controls.%20Furthermore\" target=\"_blank\" rel=\"noopener nofollow\">large Danish study<\/a> published in The Endocrinologist in 2025 found that the diagnosis of Type 1 Diabetes was 3.5 times higher in women with PCOS compared with others. It is thus recommended to get tested for blood sugar control issues promptly. <\/p>\n\n\n\n<p>Other autoimmune diseases being studied in relation to Polycystic Ovary Syndrome include Psoriasis, Systemic Sclerosis, Addison\u2019s Disease, Rheumatoid Arthritis, and Undifferentiated Connective Tissue Disease. <\/p>\n\n\n<div class=\"su-box su-box-style-soft\" id=\"\" style=\"border-color:#7a1312;border-radius:10px;\"><div class=\"su-box-title\" style=\"background-color:#AD4645;color:#FFFFFF;border-top-left-radius:8px;border-top-right-radius:8px\">Warning<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:8px;border-bottom-right-radius:8px\"> Never take autoimmune cleanse supplements, detox kits, or hormone-balancing pills without medical advice. Their ingredients can interfere with existing medications, fertility treatment, or PCOS care. They can also cause adverse effects, mislead test results and delay proper diagnosis.  <\/div><\/div>\n\n\n\n<h2 id=\"when-to-see-a-doctor-for-a-detailed-screening\" class=\"wp-block-heading\">When to see a doctor for a detailed screening?<\/h2>\n\n\n\n<p>If your symptoms are new, worsening, or no longer match your usual PCOS pattern, it is important to discuss the same with your doctor. You should seek medical advice if:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Your periods suddenly become irregular, very heavy, or stop for several months.<\/li>\n\n\n\n<li>Acne, facial hair growth, or hair loss worsens quickly.<\/li>\n\n\n\n<li>You notice rapid weight gain or unexplained weight loss. <\/li>\n\n\n\n<li>You have persistent fatigue, temperature sensitivity and constipation.<\/li>\n\n\n\n<li>You have a family history of autoimmune disease.<\/li>\n<\/ul>\n\n\n\n<p>Your healthcare provider will guide you through the next steps, such as thyroid function tests, autoimmune testing or a comprehensive hormone panel. <\/p>\n\n\n<div id=\"goodr-504341045\"><a href=\"https:\/\/www.goodrxmedicine.com\/women-s-health.html\" aria-label=\"Your Banner CTA\" class=\"post-inside-cta\">\r\n    <picture>\r\n        <source media=\"(max-width: 768px)\" srcset=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2025\/07\/Womens_Mobile.webp\">\r\n        <img decoding=\"async\" src=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2025\/07\/Womens_Desktop-scaled.webp\" alt=\"Your Banner CTA\" width=\"100%\" height=\"184\">\r\n    <\/picture>\r\n<\/a>\r\n<div style=\"height: 30px;\"><\/div><\/div>\n\n\n\n<h2 id=\"conclusion\" class=\"wp-block-heading\">Conclusion<\/h2>\n\n\n\n<p>Polycystic Ovary Syndrome, or PCOS, is not an autoimmune disease. It is a hormonal and metabolic endocrine disorder which has now been renamed as Polyendocrine Metabolic Ovarian Syndrome (PMOS). Because it can co-occur with chronic inflammation, insulin resistance, autoimmune markers and shared genetic risk factors, it is often confused with autoimmunity. <\/p>\n\n\n\n<p>Research suggests that some autoimmune conditions, especially Hashimoto\u2019s Thyroiditis, Lupus and Type 1 Diabetes, are more common in women with PCOS. The greater vulnerability is due to hormonal changes that can affect the immune system response. This means it can make some women more vulnerable to autoimmunity, but it does not mean every woman will develop one. <\/p>\n\n\n\n<p>However, if your symptoms feel different from your usual PCOS pattern, consult your doctor. Ask them whether thyroid testing or antibody screening is required based on your symptoms and family history. Seek further medical guidance from a specialist, depending on the results and diagnosis. <\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 id=\"frequently-asked-questions\" class=\"wp-block-heading\">Frequently Asked Questions<\/h2>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-question-17819477797840\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Is PCOS an inflammatory disease?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>No, PCOS is not classified as an inflammatory disease. It is an endocrine and metabolic disorder. Even though chronic low-grade inflammation is common in many women with Polycystic Ovary Syndrome, this alone does not confirm autoimmunity either.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-17819477797841\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Should I get autoimmune tests if I have PCOS?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>No, you do not need to get autoimmune tests just because you have PCOS. You should discuss it if you have a family history of autoimmune disease. Moreover, if you experience persistent fatigue, hair loss or weight changes, discuss thyroid function tests or thyroid antibody testing with your doctor. <\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-17819477797842\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Can I have PCOS and an autoimmune disease at the same time?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Yes, you can have PCOS and an autoimmune disease at the same time. Conditions like Hashimoto\u2019s Thyroiditis, Type 1 Diabetes, Rheumatoid Arthritis and Lupus can occur alongside it. <\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-17819477797843\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Is Endometriosis an autoimmune disease? <\/h3>\n<div class=\"rank-math-answer \">\n\n<p>No, Endometriosis is not classified as an autoimmune disease. However, it is linked with systemic inflammation and immune dysfunction, which is why researchers continue to study the connection. <\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"su-note\"  style=\"border-color:#cbcac8;border-radius:10px;-moz-border-radius:10px;-webkit-border-radius:10px;\"><div class=\"su-note-inner su-u-clearfix su-u-trim\" style=\"background-color:#E5E4E2;border-color:#ffffff;color:#36454F;border-radius:10px;-moz-border-radius:10px;-webkit-border-radius:10px;\"><strong>Citations:<\/strong><br \/>\n  When referencing outside resources, <a href=\"https:\/\/www.goodrxmedicine.com\" target=\"_blank\" rel=\"noopener\">GoodrxMedicine<\/a> always provides full citations. To learn more about the measures we use to maintain the quality of our content, please review our <a href=\"https:\/\/www.goodrxmedicine.com\/content-information-policy\" target=\"_blank\" rel=\"noopener\">Content Information Policy<\/a>.<\/div><\/div>\n<ul>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38922413\/#:~:text=A%20total%20of%2035%20studies%20with%2012%2C365%2C646%20subjects%20were%20retrieved.%20The%20mean%20age%20ranged%20from%2010%2D45%20years.%20Global%20prevalence%20of%20PCOS%20was%209.2%25%20(95%25%20CI%3A%206.8%2D12.5%25)%20based%20on%20meta%2Danalysis\" target=\"_blank\" rel=\"noopener nofollow\">PubMed<\/a><\/li>\n<li><a href=\"https:\/\/acrabstracts.org\/abstract\/prevalence-of-systemic-autoimmune-diseases-in-polycystic-ovary-syndrome\/#:~:text=The%20rheumatic%20disorders%20and%20relevant%20laboratory%20data%20were%20compared%20between%20the%20two%20groups%20and%20are%20summarized%20(Tables%201%20and%202).%20Our%20study%20showed%20that%20the%20frequency%20of%20RA%20was%202.25%25%20in%20PCOS%20group%20and%201.26%25%20in%20control%20(p%3D0.0747).\" target=\"_blank\" rel=\"noopener nofollow\">American College of Rheumatology<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Polycystic Ovary Syndrome (PCOS) is a hormonal and metabolic disorder in women. It can affect ovulation, blood sugar balance, skin, hair growth, mood, and quality of life. According to a 2024 meta-analysis, the condition affects 9.2% of women of reproductive age globally. On the other hand, autoimmunity is diagnosed when your immune system mistakenly attacks &#8230; <a title=\"Is PCOS an Autoimmune Disease or a Metabolic Disorder?\" class=\"read-more\" href=\"https:\/\/www.goodrxmedicine.com\/blog\/womens-health\/is-pcos-an-autoimmune-disease\/\" aria-label=\"Read more about Is PCOS an Autoimmune Disease or a Metabolic Disorder?\">Read more<\/a><\/p>\n","protected":false},"author":20,"featured_media":445567,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"schema_drug_name":"","schema_drug_sameas":"","schema_strip_mentions_drug":"","custom_head_after_canonical":"","geo_latitude":"","geo_longitude":"","footnotes":""},"categories":[155],"tags":[2087,2089,2086,2056,2088,2085],"class_list":["post-445566","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-womens-health","tag-hormonal-disorders-in-women","tag-immune-system-and-reproductive-health","tag-inflammation-and-pcos","tag-insulin-resistance-and-pcos","tag-pcos-and-autoimmune-disease-myths","tag-polycystic-ovary-syndrome-causes"],"rankmath_meta":{"title":"Is PCOS an Autoimmune Disease: What Women Should Know","description":"No, PCOS is not an autoimmune disease, but a hormonal and metabolic disorder. Learn the connection between the two and when to get tested for inflammation."},"_links":{"self":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts\/445566","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/comments?post=445566"}],"version-history":[{"count":2,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts\/445566\/revisions"}],"predecessor-version":[{"id":445569,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts\/445566\/revisions\/445569"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/media\/445567"}],"wp:attachment":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/media?parent=445566"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/categories?post=445566"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/tags?post=445566"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}