Sex Hormone Binding Globulin (SHBG) is a protein mainly produced by the liver. It binds to sex hormones like estradiol (the primary form of estrogen), testosterone, and Dihydrotestosterone (DHT). After binding, SHBG transports these hormones through the bloodstream and controls the amount of free hormones available to the body. As a result, SHBG regulates the levels of free sexual hormones in your body. <\/p>\n\n\n\n
SHBG is generally higher in females than in males, with a normal range being 18-144 nmol\/L. Higher levels help regulate free testosterone and prevent excess testosterone-related effects, such as unwanted facial hair and irregular periods. However, excessively high SHBG levels lead to hormonal imbalance and affect the reproductive system. <\/p>\n\n\n\n
High SHBG in females generally results from pregnancy, Hyperthyroidism, and contraceptive pills. Strategies such as medication adjustments and lifestyle changes can help lower SHBG levels. This article explains high SHBG levels in women, including symptoms, causes, diagnosis, treatment options, and when to consult a doctor. <\/p>\n\n\n\n
High levels of Sex Hormone Binding Globulin, above 130-150 nmol\/L, depending on the laboratory tests, indicate the liver cells are overproducing the hormone. An excess of SHBG will mean a large amount of your sex hormones will attach to it, becoming less available for the body to use. In turn, it creates a functional deficiency of sex hormones, affecting reproductive health, energy, and mood. <\/p>\n\n\n\n
If SHBG levels remain persistently high, low available estrogen can affect bone health. Estrogen maintains bone density, so low estrogen levels can increase the risk of Osteoporosis in postmenopausal women. Along with bone-related changes, excessive SHBG levels can cause other symptoms that can help identify this hormonal imbalance. <\/p>\n\n\n