{"id":404479,"date":"2023-10-03T17:24:00","date_gmt":"2023-10-03T17:24:00","guid":{"rendered":"https:\/\/www.goodrxmedicine.com\/blog\/?p=404479"},"modified":"2026-07-16T06:55:36","modified_gmt":"2026-07-16T06:55:36","slug":"eliquis-vs-xarelto","status":"publish","type":"post","link":"https:\/\/www.goodrxmedicine.com\/blog\/heart-and-blood-pressure\/eliquis-vs-xarelto\/","title":{"rendered":"Understanding the Difference: Eliquis vs Xarelto"},"content":{"rendered":"\n<p>Eliquis and Xarelto are two commonly prescribed medicines for preventing blood clots and reducing the risk of stroke.<br><br>However, some differences between Eliquis and Xarelto can influence the choice between them.&nbsp;<br><br>Let us explore the working of the two medicines and compare Eliquis vs Xarelto to help you make an informed decision.<\/p>\n\n\n\n<h2 id=\"working-of-eliquis-and-xarelto\" class=\"wp-block-heading\">Working of Eliquis and Xarelto<\/h2>\n\n\n\n<p>Eliquis and Xarelto are oral anticoagulant medications that work by blocking the &#8216;factor Xa enzyme.&#8217;&nbsp;<br><br>Factor Xa is an enzyme that helps in the formation of blood clots to prevent excessive bleeding during an injury.<br><br>However, some medical conditions may cause excess blood clot formation in the body.<br><br>Excess clotting can lead to health problems like strokes, heart attacks, and pulmonary embolisms.&nbsp;<br><br>Eliquis and Xarelto slow down factor Xa and reduce the chances of excessive clot formation.<br><br>Consult a doctor before starting any anticoagulant medications.<\/p>\n\n\n<div class=\"su-box su-box-style-soft\" id=\"\" style=\"border-color:#073d11;border-radius:10px;max-width:none\"><div class=\"su-box-title\" style=\"background-color:#3A7044;color:#FFFFFF;border-top-left-radius:8px;border-top-right-radius:8px\">Fact:<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:8px;border-bottom-right-radius:8px\"> <strong>Anticoagulant medications:<\/strong> These medicines help prevent blood clots by blocking clotting factors. <\/div><\/div>\n\n\n<div id=\"goodr-3541757964\"><!-- ===== GRX 4-Product Strip Dynamic API \u2014 GoodRxMedicine ===== -->\r\n<div class=\"grx-ss\" aria-label=\"Related products\">\r\n  <style>\r\n    .grx-ss{\r\n      --gap:12px;\r\n      --radius:12px;\r\n      --border:#d5d7da;\r\n      --muted:#717680;\r\n      --title:#181d27;\r\n      --price:#32c900;\r\n      --btn:#4107a1;\r\n      --btn-h:#32067c;\r\n      --btn-txt:#fff;\r\n      --shadow:0 4px 14px rgba(9,30,66,.06);\r\n      --v-xs:4px; --v-sm:6px;\r\n      --img-h:153px;\r\n      --wp--style--block-gap:0 !important;\r\n      display:block; width:100%; margin:0; padding:0; text-align:left;\r\n      margin-bottom:30px;\r\n    }\r\n\r\n    .grx-ss *, .grx-ss *::before, .grx-ss *::after{\r\n      box-sizing:border-box;\r\n    }\r\n\r\n    \/* Reset heading margins that themes inject *\/\r\n    .grx-ss .card h1.title,\r\n    .grx-ss 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fetchProduct(product) {\r\n        const apiUrl = API_BASE + encodeURIComponent(product.urlKey);\r\n        const response = await fetch(apiUrl, { method: \"GET\", cache: \"no-store\" });\r\n        if (!response.ok) {\r\n          throw new Error(\"API error for \" + product.urlKey + \": \" + response.status);\r\n        }\r\n        return response.json();\r\n      }\r\n\r\n      async function initProducts() {\r\n        try {\r\n          const cards = await Promise.all(\r\n            products.map(async function (product) {\r\n              const apiData = await fetchProduct(product);\r\n              return renderCard(product, apiData);\r\n            })\r\n          );\r\n          grid.innerHTML = cards.join(\"\");\r\n        } catch (error) {\r\n          console.error(\"CMS product API error:\", error);\r\n          grid.innerHTML = \"\";\r\n        }\r\n      }\r\n\r\n      initProducts();\r\n    })();\r\n  <\/script>\r\n<\/div>\r\n<!-- ===== \/GRX 4-Product Strip Dynamic API \u2014 GoodRxMedicine ===== --><\/div>\n\n\n\n\n\n\n<h2 id=\"ingredients-and-efficiency-comparison\" class=\"wp-block-heading\">Ingredients and efficiency comparison<\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2023\/07\/fda-incontent-1024x536.webp\" alt=\"FDA approval sign\" class=\"wp-image-400098\"\/><figcaption class=\"wp-element-caption\">Always buy medicines online from FDA-approved vendors<\/figcaption><\/figure>\n\n\n\n<p>Eliquis and Xarelto are both anticoagulant medications, but they both have different active ingredients.<br><br>The active ingredient in Eliquis is Apixaban.  On the other hand, the active ingredient in Xarelto is Rivaroxaban.<br><br> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557502\/#:~:text=FDA%20Approved%20Indications,other%20risk%20factors.\" target=\"_blank\" rel=\"nofollow noopener\">Rivaroxaban<\/a> (Xarelto) and <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507910\/#:~:text=FDA%2Dapproved%20Indications,therapy.%5B8%5D\" target=\"_blank\" rel=\"nofollow noopener\">Apixaban<\/a> (Eliquis) are both FDA-approved for Atrial Fibrillation (AFib), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), and more.<\/p>\n\n\n\n<ul class=\"wp-block-list has-contrast-color has-base-3-background-color has-text-color has-background\">\n<li><strong>Atrial Fibrillation:<\/strong> An irregular heart rhythm can increase the risk of stroke and other heart-related problems.<\/li>\n\n\n\n<li><strong>Deep Vein Thrombosis:<\/strong> A condition when a blood clot forms in a deep vein and can lead to serious problems.<\/li>\n\n\n\n<li><strong>Pulmonary Embolism:<\/strong> A sudden lung artery blockage often caused by a blood clot that moved from somewhere else in the body.<\/li>\n<\/ul>\n\n\n\n<p>Therefore, both Eliquis and Xarelto are highly effective in helping with excess blood clots and reducing the risk of stroke.&nbsp;<br><br>However, a <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8693217\/#:~:text=Among%20Medicare%20beneficiaries%2065%20years%20or%20older%20with%20atrial%20fibrillation%2C%20treatment%20with%20rivaroxaban%20compared%20with%20apixaban%20was%20associated%20with%20a%20significantly%20increased%20risk%20of%20major%20ischemic%20or%20hemorrhagic%20events.\" target=\"_blank\" rel=\"nofollow noopener\">study<\/a> states that Rivaroxaban (Xarelto) treatment has more risk of major ischemic or hemorrhagic events than Apixaban (Eliquis).<br><br>Another <a href=\"https:\/\/www.pennmedicine.org\/news\" target=\"_blank\" rel=\"nofollow noopener\">research<\/a> states that Apixaban is better than Rivaroxaban in preventing stroke or systemic embolism in atrial fibrillation and valvular heart disease patients.<br><br>Therefore, Eliquis is a more stable and safe medicine than Rivaroxaban.<\/p>\n\n\n<div class=\"su-box su-box-style-soft\" id=\"\" style=\"border-color:#075380;border-radius:7px;max-width:none\"><div class=\"su-box-title\" style=\"background-color:#3A86B3;color:#FFFFFF;border-top-left-radius:5px;border-top-right-radius:5px\">Buy Now<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:5px;border-bottom-right-radius:5px\"> Looking for medicines to help with stroke prevention &#038; clot reduction. Buy <a class=\"wpil_keyword_link\" href=\"https:\/\/www.goodrxmedicine.com\/eliquis-2-5-mg.html\" target=\"_blank\" rel=\"noopener\" title=\"Eliquis 2.5 Mg\" data-wpil-keyword-link=\"linked\">Eliquis 2.5 Mg<\/a> and <a class=\"wpil_keyword_link\" href=\"https:\/\/www.goodrxmedicine.com\/eliquis-5-mg.html\" target=\"_blank\" rel=\"noopener\" title=\"Eliquis 5 Mg\" data-wpil-keyword-link=\"linked\">Eliquis 5 Mg<\/a> from GoodRXMedicine now. <\/div><\/div>\n\n\n\n<h2 id=\"dosage-comparison\" class=\"wp-block-heading\">Dosage comparison<\/h2>\n\n\n\n<p>Eliquis and Xarelto are both oral medications, but they differ in dosage and administration.<br><br>The dosage of both medicines depends on the medical problem for which one is using the medicine.<br><br>Eliquis is available in the <a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/apixaban-oral-route\/description\/drg-20060729\" data-type=\"link\" data-id=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/apixaban-oral-route\/description\/drg-20060729\" target=\"_blank\" rel=\"nofollow noopener\">dosage<\/a> of 2.5, 5, and 10 mg. The medicine is taken twice a day.<br><br>On the other hand, Xarelto is available in the dosage of 2.5, 5, 10, 15, and 20 mg.&nbsp;<br><br>Xarelto is also taken twice daily and should be taken with food to enhance absorption.<br><br>However, one should always consult a doctor for proper Eliquis and Xarelto dosage according to their medical conditions.&nbsp;<\/p>\n\n\n<div class=\"su-box su-box-style-soft\" id=\"\" style=\"border-color:#075380;border-radius:7px;max-width:none\"><div class=\"su-box-title\" style=\"background-color:#3A86B3;color:#FFFFFF;border-top-left-radius:5px;border-top-right-radius:5px\">Buy now<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:5px;border-bottom-right-radius:5px\"> Buy <a class=\"wpil_keyword_link\" href=\"https:\/\/www.goodrxmedicine.com\/eliquis-2-5-mg.html\" target=\"_blank\" rel=\"noopener\" title=\"Eliquis 2.5 Mg\" data-wpil-keyword-link=\"linked\">Eliquis 2.5 Mg<\/a> from GoodRXMedicine to help with excess clot production. <\/div><\/div>\n\n\n\n<h2 id=\"cost-comparison\" class=\"wp-block-heading\">Cost comparison<\/h2>\n\n\n\n<p>Eliquis and Xarelto are both expensive medicines.<br><br>However, the cost of the medicines may vary depending on your insurance coverage and location.&nbsp;<br><br>One may look for medical insurance plans or patient assistance programs when buying expensive medicines like Eliquis and Xarelto.<br><br>Consult your doctor for a budget-friendly treatment approach.&nbsp;<\/p>\n\n\n\n<h2 id=\"eliquis-vs-xarelto-a-quick-comparison\" class=\"wp-block-heading\">Eliquis vs Xarelto: A quick comparison<\/h2>\n\n\n\n<p>The comparison between Eliquis vs Xarelto can be important for people who are looking for treatment options for Atrial Fibrillation (AFib), Deep Vein Thrombosis (DVT), and more.<\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong>Eliquis vs Xarelto<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th class=\"has-text-align-center\" data-align=\"center\"><strong>Basis of difference<\/strong><\/th><th class=\"has-text-align-center\" data-align=\"center\"><strong>Eliquis<\/strong><\/th><th class=\"has-text-align-center\" data-align=\"center\"><strong>Xarelto<\/strong><\/th><\/tr><\/thead><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\"><strong>Active ingredient&nbsp;<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">Apixaban<\/td><td class=\"has-text-align-center\" data-align=\"center\">Rivaroxaban<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\"><strong>Treatment option for<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">Atrial Fibrillation (AFib), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), and more.&nbsp;<\/td><td class=\"has-text-align-center\" data-align=\"center\">Atrial Fibrillation (AFib), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), and more.&nbsp;<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\"><strong>Prescription required&nbsp;<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">Yes<\/td><td class=\"has-text-align-center\" data-align=\"center\">Yes<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\"><strong>Dosage<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">2.5, 5, and 10 (twice daily)<\/td><td class=\"has-text-align-center\" data-align=\"center\">2.5, 5, 10, 15, and 20 (twice daily)<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\"><strong>Cost&nbsp;<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\">$400 or more<\/td><td class=\"has-text-align-center\" data-align=\"center\">$400 or more<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The above table can help people make an informed choice between Eliquis and Xarelto.<br><br>However, consult a doctor before starting any medication.<\/p>\n\n\n<div class=\"su-box su-box-style-soft cms-warning-box\" id=\"\" style=\"border-color:#7a1312;border-radius:10px;max-width:none\"><div class=\"su-box-title\" style=\"background-color:#AD4645;color:#FFFFFF;border-top-left-radius:8px;border-top-right-radius:8px\">Warning:<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:8px;border-bottom-right-radius:8px\"> Anticoagulants may lead to bleeding as they reduce the blood&#8217;s ability to clot. Therefore, always consult a doctor to monitor your treatment. <\/div><\/div>\n\n\n\n<h2 id=\"key-takeawaysnbsp\" class=\"wp-block-heading\">Key Takeaways <\/h2>\n\n\n\n<p>Eliquis and Xarelto are oral anticoagulant medications that help prevent excess blood clots and reduce the risk of stroke.<br><br>However, many people are curious about their differences and want to compare Eliquis vs Xarelto.<br><br>The active ingredient and dosage range are what make the two medicines different.&nbsp;<br><br>However, both Eliquis and Xarelto are expensive, and their cost range is almost similar.&nbsp;<br><br>One should always consult a doctor for proper information on Eliquis and Xarelto according to their medical conditions.&nbsp;<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div id=\"goodr-3407200114\"><a href=\"https:\/\/www.goodrxmedicine.com\/heart-blood-pressure.html\" aria-label=\"Your Banner CTA\" class=\"post-inside-cta\">\r\n    <picture>\r\n        <source media=\"(max-width: 768px)\" srcset=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2025\/07\/Health_Mobile.webp\">\r\n        <img decoding=\"async\" src=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2025\/07\/Health_Desktop-scaled.webp\" alt=\"Your Banner CTA\" width=\"100%\" height=\"184\">\r\n    <\/picture>\r\n<\/a>\r\n<div style=\"height: 30px;\"><\/div><\/div>\n\n\n<h2 id=\"frequently-asked-questions\" class=\"wp-block-heading\">Frequently Asked Questions<\/h2>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-question-1696317958262\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">What is Eliquis or Xarelto used for?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Eliquis and Xarelto are both anticoagulant medications used to help with blood clots and reduce the risk of stroke. The medicines are prescribed for conditions like Atrial Fibrillation, Deep Vein Thrombosis (DVT), and Pulmonary Embolism (PE).<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1696317975344\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">How do I take Eliquis or Xarelto?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Both Eliquis and Xarelto are typically taken orally with water. Always follow the prescribed dosage and schedule carefully. Do not chew, break, or crush the tablets. Also, take Xarelto with food for better absorption.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1696317972712\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">What should I do if I miss a dose of Eliquis or Xarelto?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>If you missed your Eliquis or Xarelto dose, take it the same day as soon as you remember. If you are close to the time for your next dose, skip the missed dose and continue with your regular routine. However, do not double dose to make up for the one you missed.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1696317976152\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Can I drink alcohol while taking Eliquis or Xarelto?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>No, one should not drink alcohol while taking Eliquis or Xarelto, as alcohol can increase the risk of side effects of these anticoagulant medications.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1696317977065\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Can I change Eliquis or Xarelto dosage without consulting a doctor?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>No, one should not change Eliquis or Xarelto dosage without consulting a doctor. Changing dosage without medical advice may increase the risk of side effects from these medicines.<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"su-note\"  style=\"border-color:#cbcac8;border-radius:10px;-moz-border-radius:10px;-webkit-border-radius:10px;\"><div class=\"su-note-inner su-u-clearfix su-u-trim\" style=\"background-color:#E5E4E2;border-color:#ffffff;color:#36454F;border-radius:10px;-moz-border-radius:10px;-webkit-border-radius:10px;\"><strong>Citations:<\/strong><br \/>\nWhen referencing outside resources, <a href=\"https:\/\/www.goodrxmedicine.com\" target=\"_blank\" rel=\"noopener\">GoodrxMedicine<\/a> always provides full citations. To learn more about the measures we use to maintain the quality of our content, please review our <a href=\"https:\/\/www.goodrxmedicine.com\/content-information-policy\" target=\"_blank\" rel=\"noopener\">Content Information Policy<\/a>.<\/div><\/div>\n<ul>\n<li><a href=\"https:\/\/www.medicalnewstoday.com\/articles\/eliquis\" target=\"_blank\" rel=\"noopener nofollow\">medicalnewstoday.com<\/a><\/li>\n<li><a href=\"https:\/\/www.webmd.com\/drugs\/2\/drug-156265-1153\/xarelto-oral\/rivaroxaban-oral\/details\" target=\"_blank\" rel=\"noopener nofollow\">webmd.com<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"Eliquis and Xarelto are two commonly prescribed medicines for preventing blood clots and reducing the risk of stroke. However, some differences between Eliquis and Xarelto can influence the choice between them.&nbsp; Let us explore the working of the two medicines and compare Eliquis vs Xarelto to help you make an informed decision. Working of Eliquis &#8230; Read more","protected":false},"author":20,"featured_media":417472,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"schema_drug_name":"","schema_drug_sameas":"","schema_strip_mentions_drug":"","custom_head_after_canonical":"","geo_latitude":"","geo_longitude":"","csco_display_header_overlay":false,"csco_singular_sidebar":"","csco_page_header_type":"","csco_page_load_nextpost":"","csco_page_reading_time":"","csco_page_toc_navigation":"","csco_post_video_location":[],"csco_post_video_location_hash":"","csco_post_video_url":"","csco_post_video_bg_start_time":0,"csco_post_video_bg_end_time":0,"csco_post_video_bg_volume":false,"footnotes":""},"categories":[423],"tags":[290,289,288],"class_list":{"0":"post-404479","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-heart-and-blood-pressure","8":"tag-blood-clot-treatment","9":"tag-blood-thinner","10":"tag-blood-thinning-medicine","11":"cs-entry","12":"cs-video-wrap"},"_links":{"self":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts\/404479","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/comments?post=404479"}],"version-history":[{"count":9,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts\/404479\/revisions"}],"predecessor-version":[{"id":440182,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts\/404479\/revisions\/440182"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/media\/417472"}],"wp:attachment":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/media?parent=404479"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/categories?post=404479"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/tags?post=404479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}