{"id":398415,"date":"2023-07-02T15:35:27","date_gmt":"2023-07-02T15:35:27","guid":{"rendered":"https:\/\/www.goodrxmedicine.com\/blog\/?p=398415"},"modified":"2025-11-03T12:06:48","modified_gmt":"2025-11-03T12:06:48","slug":"cialis","status":"publish","type":"post","link":"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/cialis\/","title":{"rendered":"Cialis: Working, Dosage, and Side Effects"},"content":{"rendered":"\n

Cialis, with the active salt Tadalafil, is widely regarded as a game changer in the treatment of Erectile Dysfunction (ED). Unlike other medications in its class, it is also referred to as the weekend pill due to its long-lasting effects, allowing users greater freedom and spontaneity in their sexual relationships. <\/p>\n\n\n\n

Cialis’ quick start and the possibility of daily low-dose usage have made it the favorite choice for millions of people worldwide. This article will explore every aspect of this magic pill, including its uses, workings, dosage, administration, side effects, and interactions.<\/p>\n\n\n

What is Cialis, and how does it work?<\/h2>\n\n\n

Cialis was manufactured by Eli Lilly and approved for treating Erectile Dysfunction<\/a> by the U.S. Food and Drug Administration (FDA) in 2003. Like Viagra, this tablet also belongs to a category of medications called Phosphodiesterase Type 5 (PDE5) inhibitors. The medicine works<\/a> by improving the natural process of obtaining an erection during sexual stimulation. <\/p>\n\n\n\n

On sexual arousal, Nitric Oxide (NO) is produced, triggering the synthesis of cyclic Guanosine Monophosphate (cGMP). cGMP relaxes the penile smooth muscles and widens the blood vessels, enabling more blood to enter the penis, resulting in an erection.<\/p>\n\n\n\n

But the PDE5 enzyme breakdown cGMP, thereby preventing erection<\/a>. Cialis inhibits this PDE5 enzyme, extending the activity of cGMP and permitting a stronger and longer-lasting erection. <\/p>\n\n\n\n

Beyond ED, Cialis is also approved to treat Benign Prostatic Hyperplasia (BPH), an enlarged prostate, by widening the muscles in the prostate and bladder. It is also effective for Pulmonary Arterial Hypertension (PAH), High Blood Pressure inside the lungs, by relaxing blood arteries in the lungs to reduce blood pressure.<\/p>\n\n\n\n

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