{"id":396711,"date":"2023-05-29T11:55:16","date_gmt":"2023-05-29T11:55:16","guid":{"rendered":"https:\/\/www.goodrxmedicine.com\/blog\/?p=396711"},"modified":"2025-10-30T07:20:05","modified_gmt":"2025-10-30T07:20:05","slug":"tadalafil-side-effects","status":"publish","type":"post","link":"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/tadalafil-side-effects\/","title":{"rendered":"Tadalafil Side Effects and How to Manage Them Well"},"content":{"rendered":"\n<p>Tadalafil, sold under the brand Cialis, is a commonly prescribed medicine for Erectile Dysfunction (ED) and Benign Prostatic Hyperplasia (BPH). Its potential to increase blood flow and sexual performance has made it a popular option among millions of men or Assigned Males at Birth (AMABs).&nbsp;<\/p>\n\n\n\n<p>However, while its advantages are well recognized, Tadalafil&#8217;s negative consequences are sometimes disregarded and, in some circumstances, misinterpreted. From minor headaches to significant issues such as extended erections, understanding what to expect can significantly affect secure and effective usage.&nbsp;<\/p>\n\n\n\n<p>Whether you&#8217;re considering Tadalafil for the first time or have been taking it regularly, you should be aware of its adverse effects. This article will cover the full range of Tadalafil side effects, including what is common, what is rare, and when you should seek medical attention.<\/p>\n\n\n\n<h2 id=\"common-tadalafil-side-effects\" class=\"wp-block-heading\">Common Tadalafil Side Effects<\/h2>\n\n\n\n<p>Common side effects of <a href=\"https:\/\/www.goodrxmedicine.com\/men-s-health\/tadalafil.html\" target=\"_blank\">Tadalafil<\/a> are typically mild and temporary and often improve with continued use or when the medication is discontinued. These include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Headache:<\/strong> This is the most commonly reported adverse effect, most likely caused by Tadalafil&#8217;s vasodilatory action (relaxation of blood arteries). Headaches can vary from moderate to severe.<\/li>\n\n\n\n<li><strong>Indigestion\/heartburn (Dyspepsia): <\/strong>Tadalafil can relax gastrointestinal smooth muscles, causing discomfort, upset stomach, or acid reflux.<\/li>\n\n\n\n<li><strong>Back pain and muscular aches (Myalgia):<\/strong> These are possible side effects of the medicine, which may be caused by its effect on an enzyme found in skeletal muscle.<\/li>\n\n\n\n<li><strong>Flushing:<\/strong> It is characterized by redness and warmth in the face, neck, or chest that result from vasodilation.<\/li>\n\n\n\n<li><strong>Nasal congestion\/stuffy or runny nose:<\/strong> This is mainly caused by the relaxation of blood vessels in the nasal passages.<\/li>\n\n\n\n<li><strong>Dizziness: <\/strong>Dizziness is a possible side effect of Tadalafil, often caused by its blood pressure-lowering effects, mainly when combined with alcohol or other medicines.<\/li>\n<\/ul>\n\n\n<div id=\"goodr-3319173525\"><!-- ===== GRX 4-Product Strip 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product.urlKey + \": \" + response.status);\r\n        }\r\n        return response.json();\r\n      }\r\n\r\n      async function initProducts() {\r\n        try {\r\n          const cards = await Promise.all(\r\n            products.map(async function (product) {\r\n              const apiData = await fetchProduct(product);\r\n              return renderCard(product, apiData);\r\n            })\r\n          );\r\n          grid.innerHTML = cards.join(\"\");\r\n        } catch (error) {\r\n          console.error(\"CMS product API error:\", error);\r\n          grid.innerHTML = \"\";\r\n        }\r\n      }\r\n\r\n      initProducts();\r\n    })();\r\n  <\/script>\r\n<\/div>\r\n<!-- ===== \/GRX 4-Product Strip Dynamic API \u2014 GoodRxMedicine ===== --><\/div>\n\n\n\n<h2 id=\"serious-side-effects-of-tadalafil\" class=\"wp-block-heading\">Serious side effects of Tadalafil<\/h2>\n\n\n\n<p>While rare, certain side effects might be serious and require immediate medical attention, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Priapism (prolonged erection):<\/strong> It is a <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/sexual-wellness\/painful-erection\/\" target=\"_blank\">painful erection<\/a> that lasts more than four hours. Without early treatment, this can lead to irreversible penile damage, including impotence.<\/li>\n\n\n\n<li><strong>Sudden vision loss:<\/strong> This can happen in one or both eyes, perhaps due to Non-arteritic Anterior Ischemic Optic Neuropathy (NAION), and can result in irreversible blindness.<\/li>\n\n\n\n<li><strong>Sudden hearing loss:<\/strong> A sudden decline or loss of hearing, occasionally accompanied by ringing in the ears or dizziness, that can result in permanent hearing loss.<\/li>\n\n\n\n<li><strong>Allergic reaction (Anaphylaxis):<\/strong> Symptoms include hives, rash, itching, swelling on the face or throat, and difficulty breathing or swallowing. A strong allergic response can also cause a severe rash with painful blisters (such as Stevens-Johnson syndrome).<\/li>\n<\/ul>\n\n\n<div class=\"su-box su-box-style-soft\" id=\"\" style=\"border-color:#073d11;border-radius:10px;max-width:none\"><div class=\"su-box-title\" style=\"background-color:#3A7044;color:#FFFFFF;border-top-left-radius:8px;border-top-right-radius:8px\">Glossary:<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:8px;border-bottom-right-radius:8px\">Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) is a rapid, painless loss of vision caused by diminished blood flow to the optic nerve. It is frequently connected with vascular risk factors such as Diabetes, Hypertension, and, in rare cases, medications such as Tadalafil. <\/div><\/div>\n\n\n\n<h2 id=\"longterm-side-effects-of-tadalafil-in-men\" class=\"wp-block-heading\">Long-term side effects of Tadalafil in men<\/h2>\n\n\n\n<p>While Tadalafil is generally considered safe for long-term use, particularly at lower daily doses for conditions, including <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/sexual-wellness\/erectile-dysfunction\/\" target=\"_blank\">Erectile Dysfunction<\/a> or Benign Prostatic Hyperplasia. Some potential long-term side effects may develop over time.&nbsp;<\/p>\n\n\n\n<p>These side effects are uncommon but essential to be aware of, particularly in persons with underlying health concerns or those taking other medications.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Psychological dependence:<\/strong> Although not physically addictive, some men may develop a psychological dependence on Tadalafil for sexual performance.<\/li>\n\n\n\n<li><strong>Cardiovascular strain: <\/strong>Tadalafil <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/does-tadalafil-lower-blood-pressure\/\" target=\"_blank\">lowers blood pressure<\/a> slightly by relaxing blood vessels, but it may strain the heart in people with pre-existing cardiovascular conditions.<\/li>\n\n\n\n<li><strong>Liver and kidney stress:<\/strong> The liver processes Tadalafil, while the kidneys eliminate it from the body. Long-term usage, particularly in people with liver or kidney illness, may affect organ function.<\/li>\n\n\n\n<li><strong>Muscle and back pain:<\/strong> Some users experience chronic lower back and muscular problems with regular usage, which might be due to <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16034469\/#:~:text=Although%20the%20mechanism%20of%20back%20pain%20and\/or%20myalgia%20remains%20unknown%2C%20these%20events%20appear%20to%20be%20self%2Dlimiting%20and%20a%20general%20effect%20of%20phosphodiesterase%205%20inhibition.\" target=\"_blank\" rel=\"nofollow noopener\">suppression<\/a> of the Phosphodiesterase Type 5 (PDE5) enzyme in muscle tissues.<\/li>\n<\/ul>\n\n\n<div class=\"su-box su-box-style-soft cms-warning-box\" id=\"\" style=\"border-color:#7a1312;border-radius:10px;max-width:none\"><div class=\"su-box-title\" style=\"background-color:#AD4645;color:#FFFFFF;border-top-left-radius:8px;border-top-right-radius:8px\">Warning:<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:8px;border-bottom-right-radius:8px\"> Avoid combining Tadalafil with Nitrates, as it can cause a severe decline in blood pressure, which can cause dizziness and fainting. <\/div><\/div>\n\n\n\n<h2 id=\"how-to-get-rid-of-tadalafil-side-effects\" class=\"wp-block-heading\">How to get rid of Tadalafil side effects?<\/h2>\n\n\n\n<p>The following necessary precautionary measures may minimize the risk of developing potential side effects for safe and effective usage:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Always use Tadalafil exactly as your doctor recommends. Do not exceed the specified <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/tadalafil-dosage\/\" target=\"_blank\">Tadalafil dosage<\/a>.<\/li>\n\n\n\n<li>Limit or avoid alcohol while taking Tadalafil, as it may worsen side effects such as dizziness and Low Blood Pressure.<\/li>\n\n\n\n<li>Before taking Tadalafil, talk to your doctor about all of your medical problems and other medications (prescription and over-the-counter) to avoid severe <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/sexual-wellness\/tadalafil-interactions\/\" target=\"_blank\">interactions<\/a>.<\/li>\n\n\n\n<li>Drinking enough water reduces specific adverse effects, such as headaches and dizziness.<\/li>\n\n\n\n<li>Tadalafil may be consumed with or without food; however, taking it with a light meal may help decrease gastrointestinal discomfort.&nbsp;<\/li>\n\n\n\n<li>Grapefruit and <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7003282\/#sec5:~:text=Grapefruit%20juice%20could%20increase%20the%20plasma%20exposure%20of%20tadalafil%20in%20the%20body%2C%20suggesting%20that%20grapefruit%20juice%20could%20inhibit%20the%20metabolism%20of%20tadalafil.%20Patients%20using%20tadalafil%20should%20pay%20attention%20to%20food%2Ddrug%20interactions%20when%20drinking%20grapefruit%20juice.\" target=\"_blank\" rel=\"nofollow noopener\">grapefruit juice<\/a> might raise the level of Tadalafil in your blood, thereby worsening the adverse effects.<\/li>\n<\/ul>\n\n\n\n<h2 id=\"when-to-seek-medical-help\" class=\"wp-block-heading\">When to seek medical help?<\/h2>\n\n\n\n<p>Tadalafil is generally well tolerated; however, some symptoms necessitate immediate or prompt medical attention. Seek immediate medical assistance if you experience:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Chest pain, pressure, or tightness, especially if it spreads to your jaw, shoulder, or arm.<\/li>\n\n\n\n<li>Erection that lasts for more than four hours.<\/li>\n\n\n\n<li>Persistent headache, muscle, and back pain.<\/li>\n\n\n\n<li>Seizure, confusion, fainting, or inability to move parts of your body.<\/li>\n\n\n\n<li>Blurred vision or colour confusion.<\/li>\n<\/ul>\n\n\n\n<h2 id=\"conclusion\" class=\"wp-block-heading\">Conclusion<\/h2>\n\n\n\n<p>While Tadalafil is commonly used and well tolerated for conditions, including Erectile Dysfunction and Benign Prostatic Hyperplasia, it can cause several side effects, ranging from minor headaches and indigestion to more serious concerns such as vision changes, hearing loss, or prolonged erections.&nbsp;<\/p>\n\n\n\n<p>Most Tadalafil side effects are temporary and controllable, but uncommon situations need immediate medical attention. Individuals with cardiac disorders, Nitrate users, and persons with liver or kidney disorders should use Tadalafil with care and under strong medical supervision.<\/p>\n\n\n\n<p>Understanding these potential adverse effects enables users to make informed choices and take medicine properly. Always take the specified doses, avoid potentially hazardous interactions, and visit your doctor if you experience any unexpected symptoms.<\/p>\n\n\n<div id=\"goodr-1968300915\"><a href=\"https:\/\/www.goodrxmedicine.com\/men-s-health.html\" aria-label=\"Your Banner CTA\" class=\"post-inside-cta\">\r\n    <picture>\r\n        <source media=\"(max-width: 768px)\" srcset=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2025\/07\/ED_Medicines_Mobile.webp\">\r\n        <img decoding=\"async\" src=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2025\/07\/ED_Medicines_Desktop-scaled.webp\" alt=\"Your Banner CTA\" width=\"100%\" height=\"184\">\r\n    <\/picture>\r\n<\/a>\r\n<div style=\"height: 30px;\"><\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 id=\"frequently-asked-questions\" class=\"wp-block-heading\">Frequently Asked Questions<\/h2>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-question-1754481797529\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Can Tadalafil cause Anxiety or mood changes?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Yes. While not common, some people experience mood swings or moderate <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mental-health\/anxiety-disorders-what-makes-a-person-feel-anxiousness\/\" target=\"_blank\">Anxiety<\/a>, which may be associated with blood pressure variations or sleep difficulties. If the problem persists, consult your doctor about safer alternatives or dose adjustments.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1754481843067\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Does Tadalafil influence fertility or sperm count?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>No. Tadalafil has no significant effect on men&#8217;s sperm count or fertility. However, if you are attempting to conceive, long-term usage should be examined, especially when combined with other medications.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1754481844291\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Does Tadalafil cause weight gain or loss?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>No. Tadalafil is not directly related to weight fluctuations. Any fluctuation might be the consequence of lifestyle changes brought on by increased sexual confidence or adverse effects such as lower appetite or gastrointestinal discomfort.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1754481845219\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Does Tadalafil cause dry mouth or taste changes?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Yes, although this is highly unusual, some individuals report dry mouth or a metallic taste after taking Tadalafil. These symptoms are typically transient and harmless, but should be addressed if they continue.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1754481846331\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Does Tadalafil induce nosebleeds?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Yes. Though not common, Tadalafil can occasionally increase blood flow to the nasal region, which may cause moderate nosebleeds in sensitive people or those with underlying nasal disorders. Consult your doctor if the condition persists.<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"su-note\"  style=\"border-color:#cbcac8;border-radius:10px;-moz-border-radius:10px;-webkit-border-radius:10px;\"><div class=\"su-note-inner su-u-clearfix su-u-trim\" style=\"background-color:#E5E4E2;border-color:#ffffff;color:#36454F;border-radius:10px;-moz-border-radius:10px;-webkit-border-radius:10px;\"><strong>Citations:<\/strong><br \/>\nWhen referencing outside resources, <a href=\"https:\/\/www.goodrxmedicine.com\" target=\"_blank\" rel=\"noopener\">GoodrxMedicine<\/a> always provides full citations. To learn more about the measures we use to maintain the quality of our content, please review our <a href=\"https:\/\/www.goodrxmedicine.com\/content-information-policy\" target=\"_blank\" rel=\"noopener\">Content Information Policy<\/a>.<\/div><\/div>\n<ul>\n<li><a href=\"https:\/\/www.nhs.uk\/medicines\/tadalafil\/side-effects-of-tadalafil\/\" target=\"_blank\" rel=\"noopener nofollow\">NHS.UK<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK603743\/\" target=\"_blank\" rel=\"noopener nofollow\">NIH.gov<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"Tadalafil, sold under the brand Cialis, is a commonly prescribed medicine for Erectile Dysfunction (ED) and Benign Prostatic Hyperplasia (BPH). Its potential to increase blood flow and sexual performance has made it a popular option among millions of men or Assigned Males at Birth (AMABs).&nbsp; However, while its advantages are well recognized, Tadalafil&#8217;s negative consequences &#8230; Read more","protected":false},"author":20,"featured_media":427763,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"schema_drug_name":"","schema_drug_sameas":"","schema_strip_mentions_drug":"","custom_head_after_canonical":"","geo_latitude":"","geo_longitude":"","csco_display_header_overlay":false,"csco_singular_sidebar":"","csco_page_header_type":"","csco_page_load_nextpost":"","csco_page_reading_time":"","csco_page_toc_navigation":"","csco_post_video_location":[],"csco_post_video_location_hash":"","csco_post_video_url":"","csco_post_video_bg_start_time":0,"csco_post_video_bg_end_time":0,"csco_post_video_bg_volume":false,"footnotes":""},"categories":[140],"tags":[713,715,712,716,714],"class_list":{"0":"post-396711","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-mens-health","8":"tag-cialis-adverse-reactions","9":"tag-long-term-effects-of-tadalafil","10":"tag-side-effects-of-cialis","11":"tag-tadalafil-and-priapism","12":"tag-tadalafil-dosage-and-safety","13":"cs-entry","14":"cs-video-wrap"},"_links":{"self":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts\/396711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/comments?post=396711"}],"version-history":[{"count":13,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts\/396711\/revisions"}],"predecessor-version":[{"id":442599,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts\/396711\/revisions\/442599"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/media\/427763"}],"wp:attachment":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/media?parent=396711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/categories?post=396711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/tags?post=396711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}