{"id":396599,"date":"2023-05-23T12:15:32","date_gmt":"2023-05-23T12:15:32","guid":{"rendered":"https:\/\/www.goodrxmedicine.com\/blog\/?p=396599"},"modified":"2025-10-30T07:17:20","modified_gmt":"2025-10-30T07:17:20","slug":"tadalafil-interactions","status":"publish","type":"post","link":"https:\/\/www.goodrxmedicine.com\/blog\/sexual-wellness\/tadalafil-interactions\/","title":{"rendered":"A Guide on Tadalafil Interactions"},"content":{"rendered":"\n<p>Tadalafil is a medicine that can treat Erectile Dysfunction, the inability to get or maintain erections.<\/p>\n\n\n\n<p>It&#8217;s a Phosphodiesterase type 5 (PDE5) inhibitor that keeps your blood vessels dilated.&nbsp;<\/p>\n\n\n\n<p>Tadalafil increases blood flow to your penis&#8217; soft tissue, leading to an erection.&nbsp;<\/p>\n\n\n\n<p>It has a longer duration of effectiveness than other PDE5 Inhibitors.&nbsp;<\/p>\n\n\n\n<p>However, just like the majority of other medicines, Tadalafil also might have some unfavorable interactions.&nbsp;<\/p>\n\n\n\n<p>Tadalafil may interact with other pills, vitamins, herbs, diseases, or food items you may be consuming.&nbsp;<\/p>\n\n\n\n<p>These interactions can change the way Tadalafil work. This, in turn, leads to specific side effects.<\/p>\n\n\n\n<p>Thus, it is recommended that you inform your doctor about all prescription, over-the-counter medications you are taking before taking Tadalafil for Erectile Dysfunction.<\/p>\n\n\n\n<p>In this article, you will learn about Tadalafil interactions in detail.<\/p>\n\n\n\n<h2 id=\"tadalafil-interactions-with-other-medicines\" class=\"wp-block-heading\">Tadalafil interactions with other medicines<\/h2>\n\n\n\n<p>Tadalafil oral pills (also known by their brand-name <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/cialis\/\" target=\"_blank\" rel=\"noopener\">Cialis<\/a>) may interact with other medications, vitamins, or herbal supplements.&nbsp;<\/p>\n\n\n\n<p>Nitrates, <a href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/14740338.2021.1906221\" target=\"_blank\" rel=\"noopener nofollow\">GC stimulators<\/a>, Alpha-blockers, and other medications can all interact with Tadalafil.&nbsp;<\/p>\n\n\n\n<p>Doctors may not recommend Tadalafil in combination with the following medicines due to the possibility of side effects.<\/p>\n\n\n<div id=\"goodr-2746252386\"><!-- ===== GRX 4-Product Strip (WP-proof spacing) \u2014 styled like first, with updated items ===== -->\r\n<div class=\"grx-ss\" aria-label=\"Related products\">\r\n  <style>\r\n    .grx-ss{\r\n      --gap:12px;\r\n      --radius:12px; --border:#e6e6ef; --muted:#ADADAD; --title:#1f2937; --stars:#ffc107;\r\n      --price:#16a34a; --btn:#4107a1; --btn-h:#32067c; --btn-txt:#fff; --shadow:0 4px 14px rgba(9,30,66,.06);\r\n      --v-xs:4px; --v-sm:6px;\r\n      --img-h:180px;\r\n      --wp--style--block-gap:0 !important; \/* kill Gutenberg block gap inside *\/\r\n      display:block; width:100%; margin:0; padding:0; text-align:left;\r\n\r\n      \/* match first snippet\u2019s bottom spacing *\/\r\n      margin-bottom:20px;\r\n    }\r\n\r\n    .grx-ss *, .grx-ss *::before, .grx-ss *::after{ box-sizing:border-box }\r\n\r\n    \/* Nuke theme 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opacity:.9 }\r\n\r\n    .grx-ss .btn{\r\n      margin-top:auto; display:inline-block; width:100%; text-align:center; padding:12px 14px; border-radius:10px;\r\n      background:var(--btn); color:var(--btn-txt); font:700 16px\/1 Inter,system-ui,-apple-system,Segoe UI,Roboto,Arial,sans-serif; text-decoration:none;\r\n    }\r\n    .grx-ss .btn:hover{ background:var(--btn-h) }\r\n\r\n    \/* BREAKPOINTS *\/\r\n    @media (max-width:1024px){\r\n      .grx-ss .grid{ grid-template-columns:repeat(3,minmax(0,1fr)) }\r\n      .grx-ss{ --img-h:160px; }\r\n    }\r\n    @media (max-width:768px){\r\n      .grx-ss{ padding-left:8px; padding-right:8px; --img-h:140px; }\r\n      .grx-ss .grid{ grid-template-columns:repeat(2,minmax(0,1fr)); gap:8px }\r\n      .grx-ss .card{ padding:12px; border-radius:10px }\r\n      .grx-ss .title{ font-size:16px }\r\n      .grx-ss .title a{ white-space:nowrap; overflow:hidden; text-overflow:ellipsis }\r\n      .grx-ss .price{ font-size:15px }\r\n      .grx-ss .btn{ padding:10px 12px; font-size:14px; border-radius:8px }\r\n    }\r\n  <\/style>\r\n\r\n<!-- Optional heading, keep as in first -->\r\n<h2 style=\"font-size:2em; font-weight:700; font-family:Inter,system-ui,-apple-system,Segoe UI,Roboto,Arial,sans-serif; line-height:1.25; color:#1f2937; margin:0 0 20px;\">\r\n  Save up to 90% on your medicine bills\r\n<\/h2>\r\n\r\n<div class=\"grid\">\r\n  <!-- 1) Vidalista 60 -->\r\n  <article class=\"card\">\r\n    <a class=\"img blog_widgets\" href=\"https:\/\/www.goodrxmedicine.com\/vidalista-60-mg-tadalafil.html\" target=\"_blank\" rel=\"nofollow noopener\">\r\n      <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/media.goodrxmedicine.com\/media\/iopt\/catalog\/product\/cache\/470b9116ac4ca5c5b42d526a08a8f405\/v\/i\/vidalista-60-mg-2-front.webp\" alt=\"Vidalista 60 mg\" width=\"300\" height=\"300\">\r\n    <\/a>\r\n    <div class=\"generic\">TADALAFIL<\/div>\r\n    <h3 class=\"title\">\r\n      <a class=\"blog_widgets\" href=\"https:\/\/www.goodrxmedicine.com\/vidalista-60-mg-tadalafil.html\" target=\"_blank\" rel=\"nofollow noopener\">Vidalista 60 mg<\/a>\r\n    <\/h3>\r\n    <div class=\"rating\"><span class=\"stars\">\u2605\u2605\u2605\u2605\u2606<\/span><span class=\"rcount\">28<\/span><\/div>\r\n    <div class=\"start\">Starting at just<\/div>\r\n    <div class=\"price\">$35.45<small>per pack<\/small><\/div>\r\n    <a class=\"btn blog_widgets\" href=\"https:\/\/www.goodrxmedicine.com\/vidalista-60-mg-tadalafil.html\" target=\"_blank\" rel=\"nofollow noopener\">Buy Now<\/a>\r\n  <\/article>\r\n\r\n  <!-- 2) Orgie 20 mg Oral Strips -->\r\n  <article class=\"card\">\r\n    <a class=\"img blog_widgets\" href=\"https:\/\/www.goodrxmedicine.com\/orgie-20-mg-tadalafil-oral-strips.html\" target=\"_blank\" rel=\"nofollow noopener\">\r\n      <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/media.goodrxmedicine.com\/media\/catalog\/product\/cache\/38bdd449a121db415bdaf9224821e53f\/o\/r\/orgie_20.png\" alt=\"Orgie 20 mg Oral Strips\" width=\"300\" height=\"300\">\r\n    <\/a>\r\n    <div class=\"generic\">TADALAFIL STRIP<\/div>\r\n    <h3 class=\"title\">\r\n      <a class=\"blog_widgets\" href=\"https:\/\/www.goodrxmedicine.com\/orgie-20-mg-tadalafil-oral-strips.html\" target=\"_blank\" rel=\"nofollow noopener\">Orgie 20 mg Oral Strips<\/a>\r\n    <\/h3>\r\n    <div class=\"rating\"><span class=\"stars\">\u2605\u2605\u2605\u2605\u2606<\/span><span class=\"rcount\">6<\/span><\/div>\r\n    <div class=\"start\">Starting at just<\/div>\r\n    <div class=\"price\">$57.44<small>30 strips<\/small><\/div>\r\n    <a class=\"btn blog_widgets\" href=\"https:\/\/www.goodrxmedicine.com\/orgie-20-mg-tadalafil-oral-strips.html\" target=\"_blank\" rel=\"nofollow noopener\">Buy Now<\/a>\r\n  <\/article>\r\n\r\n  <!-- 3) Vidalista 40 -->\r\n  <article class=\"card\">\r\n    <a class=\"img blog_widgets\" href=\"https:\/\/www.goodrxmedicine.com\/vidalista-40-mg-tadalafil.html\" target=\"_blank\" rel=\"nofollow noopener\">\r\n      <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/media.goodrxmedicine.com\/media\/catalog\/product\/cache\/38bdd449a121db415bdaf9224821e53f\/v\/i\/vidalista-40-mg-3-front.png\" alt=\"Vidalista 40 mg\" width=\"300\" height=\"300\">\r\n    <\/a>\r\n    <div class=\"generic\">TADALAFIL<\/div>\r\n    <h3 class=\"title\">\r\n      <a class=\"blog_widgets\" href=\"https:\/\/www.goodrxmedicine.com\/vidalista-40-mg-tadalafil.html\" target=\"_blank\" rel=\"nofollow noopener\">Vidalista 40 mg<\/a>\r\n    <\/h3>\r\n    <div class=\"rating\"><span class=\"stars\">\u2605\u2605\u2605\u2605\u2606<\/span><span class=\"rcount\">27<\/span><\/div>\r\n    <div class=\"start\">Starting at just<\/div>\r\n    <div class=\"price\">$27.88<small>per pack<\/small><\/div>\r\n    <a class=\"btn blog_widgets\" href=\"https:\/\/www.goodrxmedicine.com\/vidalista-40-mg-tadalafil.html\" target=\"_blank\" rel=\"nofollow noopener\">Buy Now<\/a>\r\n  <\/article>\r\n\r\n  <!-- 4) Cenforce 100 -->\r\n  <article class=\"card\">\r\n    <a class=\"img blog_widgets\" href=\"https:\/\/www.goodrxmedicine.com\/cenforce-100.html\" target=\"_blank\" rel=\"nofollow noopener\">\r\n      <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/media.goodrxmedicine.com\/media\/iopt\/catalog\/product\/cache\/470b9116ac4ca5c5b42d526a08a8f405\/c\/e\/cenforce-100mg-front.webp\" alt=\"Cenforce 100 mg\" width=\"300\" height=\"300\">\r\n    <\/a>\r\n    <div class=\"generic\">SILDENAFIL CITRATE<\/div>\r\n    <h3 class=\"title\">\r\n      <a class=\"blog_widgets\" href=\"https:\/\/www.goodrxmedicine.com\/cenforce-100.html\" target=\"_blank\" rel=\"nofollow noopener\">Cenforce 100 mg<\/a>\r\n    <\/h3>\r\n    <div class=\"rating\"><span class=\"stars\">\u2605\u2605\u2605\u2605\u2606<\/span><span class=\"rcount\">27<\/span><\/div>\r\n    <div class=\"start\">Starting at just<\/div>\r\n    <div class=\"price\">$25.15<small>per pack<\/small><\/div>\r\n    <a class=\"btn blog_widgets\" href=\"https:\/\/www.goodrxmedicine.com\/cenforce-100.html\" target=\"_blank\" rel=\"nofollow noopener\">Buy Now<\/a>\r\n  <\/article>\r\n<\/div>\r\n\r\n<!-- ===== \/GRX 4-Product Strip ===== -->\r\n<\/div>\n\n\n\n<h3 id=\"guanylate-cyclase-gc-stimulators\" class=\"wp-block-heading\">Guanylate Cyclase (GC) Stimulators<\/h3>\n\n\n\n<p>The medications used to treat Pulmonary Arterial Hypertension are known as Guanylate Cyclase (GC) stimulators, such as Vericiguat and Riociguat.&nbsp;<\/p>\n\n\n\n<p>Both GC stimulants and <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/does-cialis-lower-blood-pressure\/\" target=\"_blank\" rel=\"noopener\">Cialis have the potential to lower blood pressure<\/a>.&nbsp;<\/p>\n\n\n\n<p>Taking Tadalafil along with a GC stimulator may result in even lower blood pressure.&nbsp;<\/p>\n\n\n\n<p>As a result, doctors are unlikely to prescribe Tadalafil in conjunction with GC stimulants.<\/p>\n\n\n\n<h3 id=\"nitrates\" class=\"wp-block-heading\">Nitrates<\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"536\" src=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2023\/04\/heart-attack-1-1024x536.webp\" alt=\"can viagra cause a heart attack\" class=\"wp-image-394326\" srcset=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2023\/04\/heart-attack-1-1024x536.webp 1024w, https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2023\/04\/heart-attack-1-300x157.webp 300w, https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2023\/04\/heart-attack-1-768x402.webp 768w, https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2023\/04\/heart-attack-1.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Heart attack<\/figcaption><\/figure>\n\n\n\n<p>Nitrate is a <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/high-blood-pressure\/in-depth\/high-blood-pressure-medication\/art-20048154#:~:text=Vasodilators%20are%20medications%20that%20open,as%20hard%2C%20reducing%20blood%20pressure.\" target=\"_blank\" rel=\"noopener nofollow\">vasodilator<\/a> used to treat or prevent anal fissures, Angina, heart failure, and Hypertension.&nbsp;<\/p>\n\n\n\n<p>If you use Tadalafil with Nitrates, your blood pressure may decrease significantly.&nbsp;<\/p>\n\n\n\n<p>Fainting and lightheadedness can result from a sudden drop in blood pressure.&nbsp;<\/p>\n\n\n\n<p>In extreme circumstances, it might result in a heart attack or stroke.<\/p>\n\n\n\n<p>Learn what happens when you combine a PDE5 inhibitor with Nitrates. <strong>Read<\/strong>: <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/sexual-wellness\/viagra-and-nitroglycerin\/\" target=\"_blank\" rel=\"noopener\">Why Viagra and Nitroglycerin Shouldn\u2019t be Taken Together?<\/a><\/p>\n\n\n<div class=\"su-box su-box-style-soft\" id=\"\" style=\"border-color:#073d11;border-radius:10px;\"><div class=\"su-box-title\" style=\"background-color:#3A7044;color:#FFFFFF;border-top-left-radius:8px;border-top-right-radius:8px\">Suggestion<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:8px;border-bottom-right-radius:8px\"> Consult your doctor before using Tadalafil if you take a Nitrate to avoid side effects. <\/div><\/div>\n\n\n\n<h3 id=\"alphablockers\" class=\"wp-block-heading\">Alpha-blockers<\/h3>\n\n\n\n<p>According to <a href=\"https:\/\/www.auajournals.org\/doi\/pdf\/10.1016\/S0022-5347%2818%2938432-5?cookieSet=1\" target=\"_blank\" rel=\"noopener nofollow\">studies<\/a>, Alpha-blockers like are used to treat Benign Prostate Hyperplasia (BPH) or high blood pressure.&nbsp;<\/p>\n\n\n\n<p>Like Cialis and <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/sexual-wellness\/is-tamsulosin-like-viagra\/\" target=\"_blank\" rel=\"noopener\">Viagra, Alpha-blockers like Tamsulosin<\/a> work by reducing blood pressure. <\/p>\n\n\n\n<p>Using Tadalafil with Alpha-blockers may lead to a dangerous drop in blood pressure.<\/p>\n\n\n\n<p>This might cause fainting or dizziness.<\/p>\n\n\n\n<h3 id=\"other-medications\" class=\"wp-block-heading\">Other medications<\/h3>\n\n\n\n<p>Tadalafil&#8217;s working can be impacted by other medications, which may change how Tadalafil functions.&nbsp;<\/p>\n\n\n\n<p>Examples include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>HIV Protease inhibitors like Fosamprenavir<\/li>\n\n\n\n<li>Azole antifungals like Itraconazole and Ketoconazole<\/li>\n\n\n\n<li>Macrolide antibiotics like Clarithromycin and Erythromycin.<\/li>\n<\/ul>\n\n\n<div class=\"su-box su-box-style-soft\" id=\"\" style=\"border-color:#073d11;border-radius:10px;\"><div class=\"su-box-title\" style=\"background-color:#3A7044;color:#FFFFFF;border-top-left-radius:8px;border-top-right-radius:8px\">Fact<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:8px;border-bottom-right-radius:8px\"> According to a report published in <a class=\"wpil_keyword_link\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5603624\/\" target=\"_blank\" rel=\"noopener nofollow\" title=\"National Library of Medicine\" data-wpil-keyword-link=\"linked\">National Library of Medicine<\/a>, Tadalafil can be effective for up to 36 hours after only one dose. <\/div><\/div>\n\n\n\n<h3 id=\"other-pde5-inhibitors\" class=\"wp-block-heading\">Other PDE5 inhibitors<\/h3>\n\n\n\n<p>Tadalafil belongs to a group of medications known as <a href=\"https:\/\/www.medicalnewstoday.com\/articles\/list-of-pde5-inhibitors#_noHeaderPrefixedContent\" target=\"_blank\" rel=\"noopener nofollow\">PDE5 inhibitors<\/a>, which help treat the <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/erectile-dysfunction-symptoms\/\" target=\"_blank\" rel=\"noopener\">symptoms of Erectile Dysfunction<\/a>.<\/p>\n\n\n\n<p>Tadalafil and other <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/erectile-dysfunction-pills\/\" target=\"_blank\" rel=\"noopener\">Erectile Dysfunction pills <\/a>from this group can reduce blood pressure.&nbsp;<\/p>\n\n\n\n<p>Combining Tadalafil with other medicines in the same family, such as Sildenafil (<a href=\"https:\/\/www.goodrxmedicine.com\/blog\/sexual-wellness\/viagra\/\" target=\"_blank\" rel=\"noopener\">Viagra<\/a>), Vardenafil (<a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/levitra\/\" target=\"_blank\" rel=\"noopener\">Levitra<\/a>), and Avanafil (Stendra), might increase the risk of low blood pressure even more.&nbsp;<\/p>\n\n\n\n<p>As a result, serious side effects may occur.<\/p>\n\n\n<div class=\"su-box su-box-style-soft\" id=\"\" style=\"border-color:#7a1312;border-radius:10px;\"><div class=\"su-box-title\" style=\"background-color:#AD4645;color:#FFFFFF;border-top-left-radius:8px;border-top-right-radius:8px\">Warning<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:8px;border-bottom-right-radius:8px\"> Do not take Tadalafil with other PDE5 Inhibitors, as it can significantly drop your blood pressure. <\/div><\/div>\n\n\n\n<h3 id=\"antibiotics\" class=\"wp-block-heading\">Antibiotics<\/h3>\n\n\n\n<p>Certain antibiotics, such as Erythromycin and Rifampin, may stop your body from metabolizing <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/sexual-wellness\/get-all-your-answers-about-tadalafil-pill\/\" target=\"_blank\" rel=\"noopener\">Tadalafil<\/a>.&nbsp;<\/p>\n\n\n\n<p>As a result, your body may have more Tadalafil than usual.&nbsp;<\/p>\n\n\n\n<p>Your chance of experiencing adverse <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/cialis-side-effects\/\" target=\"_blank\" rel=\"noopener\">side effects from Tadalafil<\/a> may rise if you have a high concentration of Tadalafil in your body.<\/p>\n\n\n\n<h3 id=\"antiseizure-medicines\" class=\"wp-block-heading\">Antiseizure medicines<\/h3>\n\n\n\n<p>Your body may break down Tadalafil faster than usual if you use particular antiseizure medications like Carbamazepine and Phenobarbital.&nbsp;<br><br>As a consequence, your body may have less Tadalafil than usual. This might reduce the ability of Tadalafil to <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/erectile-dysfunction-treatments\/\" target=\"_blank\" rel=\"noopener\">treat your Erectile Dysfunction<\/a> effectively.<\/p>\n\n\n\n<p><strong>Recommended Read:<\/strong> Learn about Tadalafil&#8217;s duration in this informative article &#8211; <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/sexual-wellness\/how-long-does-tadalafil-last\/\" target=\"_blank\" rel=\"noopener\">How Long Does Tadalafil Last? Exploring the Duration of Tadalafil\u2019s Effects<\/a><\/p>\n\n\n\n<h2 id=\"tadalafil-interactions-with-food\" class=\"wp-block-heading\">Tadalafil interactions with food<\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><a class=\"post-inside-cta\" href=\"https:\/\/www.goodrxmedicine.com\/men-s-health\/tadalafil.html\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"398\" src=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2023\/06\/GRX-CTA-8-1024x398.webp\" alt=\"ED Pills that actually work\" class=\"wp-image-420620\" srcset=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2023\/06\/GRX-CTA-8-1024x398.webp 1024w, https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2023\/06\/GRX-CTA-8-300x117.webp 300w, https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2023\/06\/GRX-CTA-8-768x299.webp 768w, https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2023\/06\/GRX-CTA-8.webp 1440w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p>Consuming Tadalafil, along with alcohol and grapefruit or grape juice, can lead to serious side effects.&nbsp;<\/p>\n\n\n\n<p>Dizziness, fainting, lightheadedness, flushing, headaches, and palpitations are some symptoms you may encounter more frequently after combining Tadalafil with alcohol or grapefruit.<\/p>\n\n\n\n<h3 id=\"alcohol\" class=\"wp-block-heading\">Alcohol<\/h3>\n\n\n\n<p>Avoid drinking <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/tadalafil-and-alcohol\/\" target=\"_blank\" rel=\"noopener\">alcohol when taking Tadalafil<\/a>.<\/p>\n\n\n\n<p>Tadalafil raises the risk of extremely low blood pressure when alcohol is consumed along with it.&nbsp;<\/p>\n\n\n\n<p>Call your doctor immediately if you experience dizziness, lightheadedness, or blurred vision.<\/p>\n\n\n\n<p><strong>Recommended read:<\/strong> Explore the article on Cialis and alcohol interactions for informed and safe usage &#8211; <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/cialis-and-alcohol\/\" target=\"_blank\" rel=\"noopener\">Do Cialis and Alcohol Interact?<\/a><\/p>\n\n\n\n<h3 id=\"grapefruit-or-grape-juice\" class=\"wp-block-heading\">Grapefruit or Grape Juice<\/h3>\n\n\n\n<p>According to a research paper published in <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7003282\/#:~:text=Grapefruit%20juice%20could%20increase%20the,interactions%20when%20drinking%20grapefruit%20juice.\" target=\"_blank\" rel=\"noopener nofollow\">NCBI<\/a>, grapefruit juice may enhance the body&#8217;s plasma exposure to Tadalafil.&nbsp;<\/p>\n\n\n\n<p>This may prevent Tadalafil from being metabolized.&nbsp;<\/p>\n\n\n\n<p>Consequently, Tadalafil&#8217;s adverse effects will increase.<\/p>\n\n\n\n<h2 id=\"tadalafil-interaction-with-diseases\" class=\"wp-block-heading\">Tadalafil interaction with diseases<\/h2>\n\n\n\n<p>The risk of interactions with Tadalafil may rise due to several diseases and other circumstances.&nbsp;<\/p>\n\n\n\n<p>If you have a history of heart diseases, blood-related disorders, kidney or liver disease, etc., consult your doctor before using Tadalafil.&nbsp;<\/p>\n\n\n\n<p>The following health issues or conditions might affect how Tadalafil works:<\/p>\n\n\n\n<h3 id=\"heart-disease-or-stroke\" class=\"wp-block-heading\">Heart disease or stroke<\/h3>\n\n\n\n<p>&nbsp;If you have a heart condition or have recently suffered a stroke, doctors usually won&#8217;t prescribe Tadalafil.<\/p>\n\n\n\n<p>Additionally, Tadalafil is not advised for those who have issues like these:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Untreated high or low blood pressure<\/li>\n\n\n\n<li>Chest discomfort&nbsp;<\/li>\n\n\n\n<li>Untreated and irregular heart rhythm&nbsp;<\/li>\n<\/ul>\n\n\n\n<h3 id=\"blood-cancers-or-problems-with-blood-cells\" class=\"wp-block-heading\">Blood cancers or problems with blood cells<\/h3>\n\n\n\n<p>If you have Blood Cancer (such as Leukaemia and <a href=\"https:\/\/www.cancer.org\/cancer\/types\/multiple-myeloma\/about\/what-is-multiple-myeloma.html\" target=\"_blank\" rel=\"noopener nofollow\">Multiple Myeloma<\/a>), inform your doctor before using Tadalafil.&nbsp;<\/p>\n\n\n\n<p>Also, tell them if you suffer from blood cell conditions, such as Sickle Cell Anemia.&nbsp;<\/p>\n\n\n\n<p>Your risk of Priapism might rise as a result of these situations.<\/p>\n\n\n<div class=\"su-box su-box-style-soft\" id=\"\" style=\"border-color:#073d11;border-radius:10px;\"><div class=\"su-box-title\" style=\"background-color:#3A7044;color:#FFFFFF;border-top-left-radius:8px;border-top-right-radius:8px\">Glossary:<\/div><div class=\"su-box-content su-u-clearfix su-u-trim\" style=\"border-bottom-left-radius:8px;border-bottom-right-radius:8px\"> <strong>Plasma exposure<\/strong> is the body&#8217;s actual exposure to a medication after the intake of the prescribed amount of the medicine.<br \/>\n<strong>Priapism:<\/strong> It is a condition in which the penis maintains an erection for an extended time without suitable stimulation. <\/div><\/div>\n\n\n\n<h3 id=\"kidney-or-liver-diseases\" class=\"wp-block-heading\">Kidney or liver diseases<\/h3>\n\n\n\n<p>Before using Tadalafil, let your doctor know if you have a liver or renal condition.&nbsp;<\/p>\n\n\n\n<p>Failures of the kidneys and the liver are two such diseases that may interact with Tadalafil.<\/p>\n\n\n\n<h2 id=\"conclusion\" class=\"wp-block-heading\">Conclusion<\/h2>\n\n\n\n<p>Tadalafil is a safe and effective treatment for Erectile Dysfunction and may be the best option for you.&nbsp;<\/p>\n\n\n\n<p>Additional factors must also be considered, such as potential side effects and medication interactions.&nbsp;<\/p>\n\n\n\n<p>Tadalafil causes <a href=\"https:\/\/www.goodrxmedicine.com\/blog\/mens-health\/tadalafil-side-effects\/\" data-type=\"link\" data-id=\"https:\/\/www.goodrxmedicine.com\/blog\/sexual-wellness\/tadalafil-side-effects\/\" target=\"_blank\">side effects<\/a> when it interacts with a number of different medications and food items.<\/p>\n\n\n\n<p>Tadalafil tablet&#8217;s label might have colored stickers on the label that describe an interaction.&nbsp;<\/p>\n\n\n\n<p>Ask your doctor to explain this information if you need clarification.<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div id=\"goodr-2843280204\"><a href=\"https:\/\/www.goodrxmedicine.com\/men-s-health\/generic-viagra.html\" aria-label=\"Your Banner CTA\" class=\"post-inside-cta\">\r\n    <picture>\r\n        <source media=\"(max-width: 768px)\" srcset=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2025\/07\/Sexual_Mobile.webp\">\r\n        <img decoding=\"async\" src=\"https:\/\/www.goodrxmedicine.com\/blog\/wp-content\/uploads\/2025\/07\/Sexual_Desktop-scaled.webp\" alt=\"Your Banner CTA\" width=\"100%\" height=\"184\">\r\n    <\/picture>\r\n<\/a>\r\n<div style=\"height: 30px;\"><\/div><\/div>\n\n\n<h2 id=\"frequently-asked-questions\" class=\"wp-block-heading\">Frequently Asked Questions<\/h2>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-question-1684837016182\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">What can you not take with Tadalafil?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>When using Tadalafil, avoid drinking large amounts of alcohol. Additionally, avoid consuming grapefruit or grapefruit juice while taking this medication.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1684837041269\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">What drugs should not be taken with Tadalafil?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Tadalafil and other medications, such as Nitrates, Azole antifungals, Alpha-blockers, Macrolide antibiotics, other PDE5 inhibitors, and others, should not be consumed together.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1684837068597\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Can you drink alcohol with Tadalafil?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>No. When using Tadalafil, restrict the consumption of alcohol.\u00a0<\/p>\n<p>Alcohol consumption in excess can raise your risk of experiencing headaches or dizziness, speed up your heartbeat, or reduce your blood pressure.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1684837092894\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Should I avoid certain foods while taking Tadalafil?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Yes. While using Tadalafil, avoid eating grapefruit or drinking grapefruit juice.\u00a0<\/p>\n<p>Grapefruit and grapefruit juice may affect how much Tadalafil is absorbed in your body.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1684837123329\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Is taking Tadalafil harmful to your heart?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Yes. People with cardiac issues may face substantial adverse effects while consuming Tadalafil.\u00a0<\/p>\n<p>Do not use Tadalafil if you also take Riociguat or any Nitrate medication frequently prescribed to treat Angina (chest pain).<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1684837155612\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Is Tadalafil affected by food?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Yes. Tadalafil may be taken before or after meals.\u00a0<\/p>\n<p>For quick results, it is better to take Tadalafil on an empty stomach.\u00a0<\/p>\n<p>A high-fat meal could slow down tadalafil&#8217;s effects.<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"su-note\"  style=\"border-color:#cbcac8;border-radius:10px;-moz-border-radius:10px;-webkit-border-radius:10px;\"><div class=\"su-note-inner su-u-clearfix su-u-trim\" style=\"background-color:#E5E4E2;border-color:#ffffff;color:#36454F;border-radius:10px;-moz-border-radius:10px;-webkit-border-radius:10px;\"><strong>Citations:<\/strong><br \/>\nWhen referencing outside resources, GoodrxMedicine always provides full citations. To learn more about the measures we use to maintain the quality of our content, please review our <a href=\"https:\/\/www.goodrxmedicine.com\/content-information-policy\" target=\"_blank\" rel=\"noopener\">Content Information Policy<\/a>.<\/div><\/div>\n<ul>\n<li><a href=\"https:\/\/www.healthline.com\/health\/drugs\/tadalafil-oral-tablet#other-warnings\" target=\"_blank\" rel=\"noopener nofollow\">healthline.com<\/a>\n<\/li>\n<li><a href=\"https:\/\/www.drugs.com\/drug-interactions\/tadalafil.html\" target=\"_blank\" rel=\"noopener nofollow\">drugs.com<\/a>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Tadalafil is a medicine that can treat Erectile Dysfunction, the inability to get or maintain erections. It&#8217;s a Phosphodiesterase type 5 (PDE5) inhibitor that keeps your blood vessels dilated.&nbsp; Tadalafil increases blood flow to your penis&#8217; soft tissue, leading to an erection.&nbsp; It has a longer duration of effectiveness than other PDE5 Inhibitors.&nbsp; However, just &#8230; <a title=\"A Guide on Tadalafil Interactions\" class=\"read-more\" href=\"https:\/\/www.goodrxmedicine.com\/blog\/sexual-wellness\/tadalafil-interactions\/\" aria-label=\"Read more about A Guide on Tadalafil Interactions\">Read more<\/a><\/p>\n","protected":false},"author":20,"featured_media":396617,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"schema_drug_name":"","schema_drug_sameas":"","schema_strip_mentions_drug":"","custom_head_after_canonical":"","geo_latitude":"","geo_longitude":"","footnotes":""},"categories":[25],"tags":[66,227,201,219],"class_list":["post-396599","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sexual-wellness","tag-erectile-dysfunction","tag-erectile-dysfunction-medicine","tag-erectile-dysfunction-treatment","tag-tadalafil"],"rankmath_meta":{"title":"Tadalafil Interactions: Knowing What To Have And What Not To","description":"Tadalafil could be the best treatment for Erectile Dysfunction. Know potential Tadalafil interactions with other medicines and food in this article."},"_links":{"self":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts\/396599","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/comments?post=396599"}],"version-history":[{"count":19,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts\/396599\/revisions"}],"predecessor-version":[{"id":442581,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/posts\/396599\/revisions\/442581"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/media\/396617"}],"wp:attachment":[{"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/media?parent=396599"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/categories?post=396599"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.goodrxmedicine.com\/blog\/wp-json\/wp\/v2\/tags?post=396599"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}