{"id":394553,"date":"2023-04-19T11:30:07","date_gmt":"2023-04-19T11:30:07","guid":{"rendered":"https:\/\/www.goodrxmedicine.com\/blog\/?p=394553"},"modified":"2026-07-22T13:13:32","modified_gmt":"2026-07-22T13:13:32","slug":"lisinopril-and-cialis","status":"publish","type":"post","link":"https:\/\/www.goodrxmedicine.com\/blog\/sexual-wellness\/lisinopril-and-cialis\/","title":{"rendered":"Everything About Taking Lisinopril and Cialis Together"},"content":{"rendered":"\n

Lisinopril and Cialis (containing the active ingredient Tadalafil) are prescription medicines commonly used for different health conditions. Lisinopril is an Angiotensin-converting Enzyme (ACE) inhibitor that treats High Blood Pressure and Heart Failure. On the other hand, Cialis is a Phosphodiesterase 5 (PDE5) inhibitor, which is mainly prescribed to treat Erectile Dysfunction (ED) and the symptoms of an enlarged prostate.<\/p>\n\n\n\n

As long-term High Blood Pressure can damage blood vessels and reduce penile blood flow, increasing the risk of ED, both these medicines are often prescribed together. Since both Lisinopril and Cialis can affect blood pressure, many people wonder whether they are safe to use together. <\/p>\n\n\n\n

In most cases, the combination is considered safe when prescribed by a healthcare professional. However, it can increase the blood pressure-lowering effect, particularly in certain individuals. This article explains the possibility of Lisinopril-Cialis interaction, possible side effects, factors that increase the risk of complications, and when to seek medical attention.<\/p>\n\n\n\n

Can you take Lisinopril and Cialis together?<\/h2>\n\n\n\n

Yes, Lisinopril and Cialis (Tadalafil<\/a>) can generally be taken together if prescribed by a healthcare professional. However, because both medicines lower blood pressure through different mechanisms, taking them together can produce an additive blood pressure-lowering effect.<\/p>\n\n\n\n

Lisinopril lowers blood pressure by blocking the production of the hormone Angiotensin II, which narrows blood vessels. This allows blood vessels to relax and reduces blood pressure. Cialis works differently by blocking the PDE5 enzyme, increasing the effects of Nitric Oxide (NO). This helps relax the smooth muscles of blood vessels and boosts blood flow, particularly to the penis during sexual stimulation. It can also cause a modest reduction in blood pressure throughout the body as a side effect.<\/p>\n\n\n\n

For most healthy individuals, this additional blood pressure reduction is mild. So, combining Lisinopril and Cialis is not contraindicated. However, before using them together, always inform your doctor for safety. <\/p>\n\n\n

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